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Endometrial Evaluation in Cases of Postmenopausal Bleeding

Endometrial Evaluation in Cases of Postmenopausal Bleeding Using Three Dimensional Ultrasound , Power Doppler Angiography and Office Hysteroscopy in Correlation to Pathological Findings .

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03847415
Enrollment
100
Registered
2019-02-20
Start date
2019-02-28
Completion date
2019-10-31
Last updated
2019-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postmenopausal Bleeding

Brief summary

The aim of this prospective observational study is to evaluate abnormal uterine bleeding in postmenopausal women using 3D(dimensional) ultrasound assessment of endometrial volume .Doppler assessment of endometrium and hysteroscopy and to correlate this finding with pathological finding of endometrial biopsy

Detailed description

Postmenopausal bleeding (PMB) is defined as vaginal bleeding occurring after twelve months of amenorrhoea, in a woman of the age where the menopause can be expected. Hence it does not apply to a young woman, who has had amenorrhoea from anorexia nervosa, or a pregnancy followed by lactation. However, it can apply to younger women following premature ovarian failure or premature menopause, Postmenopausal bleeding is a common problem representing 5% of all gynaecology outpatient attendances. postmenopausal bleeding is usually the first symptom of endometrial cancer and active intervention can lead to its early detection. So, there is need of a diagnostic tool with high accuracy for detection of endometrial pathology in most efficient and least invasive method possible. Endometrial sampling is the gold standard for diagnosing abnormalities in the endometrial tissues ,however . There is a growing trend to use noninvasive procedures such as TVS, to measure the endometrial thickness, diagnose adenomyosis, endometrial polyps .Another important ability of 3D TVS is volume calculation using the Virtual Organ Computer-aided AnaLysis (VOCAL) even in irregularly shaped structures. This method has been demonstrated to be more accurate than 2D-volume estimation . • Hysteroscopy has the advantage of directly visualizing the uterine cavity and the endometrium, allowing biopsy to be taken immediately from the suspected abnormality.

Interventions

DIAGNOSTIC_TESTultrasound

to evalute abnormal uterine bleeding in postmenopausal women using 3D(dimensional) ultrasound assessment of endometrial volume .Doppler assessment of endometrium and hysteroscopy and to correlate this finding with pathological finding of endometrial biopsy

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
45 Years to No maximum

Inclusion criteria

* Inclusion Criteria: * Women Age \> 45 years * with postmenopausal uterine bleeding

Exclusion criteria

* Women with bleeding disorders or coagulopathy * women with cervical cancer or breast carcinoma . * history of tamoxifen intake * women with fibroid .

Design outcomes

Primary

MeasureTime frameDescription
accuracy of 3d ultrasound in post menopausal bleeding6monthsto evalute women with postmenpausal uterine bleeding using three dimensional ultrasound assessment of endometrial volume

Secondary

MeasureTime frameDescription
comparison between hysteroscopy and ultrasound in post menopausal bleeding6monthsto compare hysteroscopy with ultrasound

Contacts

Primary ContactMohamed Reda, M.D
mo.reda2011@yahoo.com+201000769315
Backup ContactAhmed Aref

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026