Light-to-moderate Alcohol Consumption, Nonalcoholic Fatty Liver Disease, Type2 Diabetes Mellitus
Conditions
Brief summary
This study explored the cross-sectional and prospective associations between light-to-moderate alcohol consumption (LMAC) and risk of type 2 diabetes mellitus (T2DM) in individuals with nonalcoholic fatty liver disease (NAFLD).
Interventions
None listed
Sponsors
Ningbo No. 1 Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. aged 18 years or above 2. undergoing annual health examinations in 2009 in Zhenhai Lianhua Hospital, Ningbo, China. 3. informed about the study
Exclusion criteria
1. female participants; 2. missing data on ultrasound, alcohol consumption, and T2DM status; 3. alcohol consumption \> 210 g per week, and binge drinkers; 4. with evidence of other liver diseases including viral hepatitis, autoimmune hepatitis, and drug-induced liver disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Light-to-moderate alcohol consumption (LMAC) and risk of prevalent type 2 diabetes mellitus (T2DM) | cross-sectional analyses in 2009 | Fatty liver was assessed by ultrasound. T2DM was defined as the presence of any of the following conditions based on American Diabetes Association criteria: (1) fasting plasma glucose (FPG) ≥ 7.0 mmol/L; (2) hemoglobin A1c (HbA1c) ≥ 6.5%; (3) self-reported clinician-diagnosed T2DM. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| LMAC and incident risk of T2DM | 9-year cohort observation | Fatty liver was assessed by ultrasound. T2DM was defined as the presence of any of the following conditions based on American Diabetes Association criteria: (1) fasting plasma glucose (FPG) ≥ 7.0 mmol/L; (2) hemoglobin A1c (HbA1c) ≥ 6.5%; (3) self-reported clinician-diagnosed T2DM. |
Countries
China
Outcome results
None listed