Cardiovascular Diseases, Diabetes, Environmental Exposure, Metabolic Syndrome, Nutritional and Metabolic Diseases, Obesity, Risk Factor, Cardiovascular
Conditions
Brief summary
Tongji-Ezhou study (TJEZ) is a prospective cohort study launched at 2013 in EZhou city, Hubei province, with the goal of recruiting and assessing 10,000 individuals and then following them for at least 2 decades. In addition, blood samples would be collected every 3-5 years among 6000 of them to investigate the nutritional biomarkers and potential determinants of chronic diseases such as obesity, type 2 diabetes, metabolic syndrome, and cardiovascular disease.
Interventions
OTHERDietary and environmental exposure (Observational study)
Sponsors
Huazhong University of Science and Technology
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Inclusion criteria
* (i) permanent residence in Ezhou district (minimum of 9 months); (ii) written informed consent; (iii) age ≥ 20 years old at the time of enrolling in the study.
Exclusion criteria
* (i) with chemotherapy or radiotherapy for cancer and other severe diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of diabetes | 5 years | Type 2 diabetes was diagnosed when FPG ≥ 7.0 mmol/L and/or OGTT2h ≥ 11.1 mmol/L, or using diabetic medication (self-report). |
| Incidence of metabolic syndrome | 5 years | Metabolic syndrome is defined as using the updated National Cholesterol Education Program/Adult Treatment Panel III criteria for Asian Americans. These criteria require three or more of the following components: (1) central obesity (waist circumference of ≥90 cm for men or ≥80 cm for women), (2) triglycerides of ≥1.7 mmol/L, (3) HDL-C of \<1.03 mmol/L for men or \<1.30 mmol/L for women, (4) blood pressure of ≥130/85 mmHg or on medication for hypertension, and (5) fasting glucose of ≥5.6 mmol/L. |
| Diabetic complications | mean follow up of 10 years | Development of diabetic complications |
| Incidence of cardiovascular diseases | mean follow up of 10 years | Cardiovascular death, stroke, myocardial infarction, heart failure |
Countries
China
Outcome results
None listed