Laparoscopic Adrenalectomy, Nerve Block, Pain Management
Conditions
Brief summary
This prospective, randomized ,control study aims to compare the analgesic effect,quality of recovery, length of hospital stay ,et al. between single-injection QLB(quadratus lumborum block)+general anesthesia (GA) and general anesthesia (GA) alone in patients undergoing laparoscopic adrenalectomy.
Interventions
Inject 0.4ml/kg 0.5% ropivacaine between quadratus lumborum and psoas major without continuous local infusion Device: Ultrasound Scanner The curved (C1-5) probe of Ultrasound Scanner is used for scan Device: PAJUNK StimuLong Drug: single dose ropivacaine 0.4ml/kg 0.5% ropivacaine given immediately after the correct position of the tip of the needle has been verified.
PROCEDUREPlacebo control
Inject 0.4ml/kg saline between quadratus lumborum and psoas major without continuous local infusion Device: Ultrasound Scanner The curved (C1-5) probe of Ultrasound Scanner is used for scan Device: PAJUNK StimuLong Drug: single dose 0.4ml/kg 0.9% NS. given immediately after the correct position of the tip of the needle has been verified.
Sponsors
Peking Union Medical College Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-70 yrs * American Society of Anesthesiologists physical statusⅠ-Ⅲ * Undergo laparoscopic adrenalectomy * Informed consent
Exclusion criteria
* A known allergy to the drugs being used * Coagulopathy, on anticoagulants * Analgesics intake, history of substance abuse * Participating in the investigation of another experimental agent * Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain numeric rating scale (NRS, 0-10)pain score at activity at 12 hours after surgery | At 12hours after the surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| incidence of postoperative nausea and vomiting (PONV) | within 24 postoperative hours | — |
| ambulation time | within5 days after surgery | — |
| time of restart anal exhaust | within 5 days after surgery | — |
| The pain scores at rest determined by the numeric rating scale (NRS, 0-10) | At 2,4, 8, 12,24 ,48,72hours after the surgery | — |
| patient's satisfaction with anesthesia and analgesia | 48 hours after surgery | use the Chinese version Bauer questionnaire to assess the patient satisfaction with anesthesia and analgesia |
| The pain scores at activity determined by the numeric rating scale (NRS, 0-10) | At 2,4, 8, 24 ,48,72hours after the surgery | — |
| Postoperative length of hospital stay | up to2 weeks after surgery | — |
Countries
China
Outcome results
None listed