Myocarditis Acute, Ventricular Arrythmia
Conditions
Brief summary
The study aims to assess the prevalence of ventricular rhythmic disorder after an acute myocarditis in sportsmen. 50 patients with acute myocarditis, confirmed by MRI, will be assessed by ECG Holter and Treadmill stress test during a 1-year follow-up.
Interventions
DIAGNOSTIC_TESTTreadmill Stress test
Ventricular arrhythmia will be assessed by ECG Holter and during treadmill stress test, both being performed 3 months and 1 year after acute myocarditis
Sponsors
University Hospital, Angers
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* acute myocarditis, diagnosed on the association of (a) recent viral infection (upper airway, gastro-intestinal) , (b) troponin increase, and (c) chest pain AND myocarditis confirmed by cardiac magnetic resonance 2 out of 3 Lake Louise criteria, either T2 hypersignal, early enhancement or late gadolinium enhancement. * regular physical activity, recreational or competitive: \>=4 hours weekly * written informed consent
Exclusion criteria
* coronary artery disease * acute inflammatory cardiomyopathy (sarcoidosis, fulminant myocarditis, Tako Tsubo, eosinophilic myocarditis, Lyme disease) * history of myocarditis * contra-indication to cardiac MRI * patient unable to perform a treadmill stress test
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Complex ventricular arrhythmia | any timepoint: 3 month and/or 1 year | any ventricular tachycardia (triplet or more), ventricular fibrillation (observed on ECG Holter or during stress test) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| In-hospital ventricular arrhythmia | up to 2 weeks after admission | any ventricular tachycardia (triplet or more), ventricular fibrillation, recorded on ECG monitoring |
| Left Ventricular remodeling | between baseline and 3 months | Change in LV volumes during time |
| Left ventricular fibrosis | between baseline and 3 months | Change in interstitial fibrosis by T1 mapping cardiac magnetic resonnance |
| Major adverse cardio vascular event | up to 2 years after inclusion | CV death, sudden cardiac death, cardiac graft or haemodynamic support, hospitalisation for heart failure, new event of myocarditis |
| return to physical activity | up to 2 years after inclusion | defined as at least 75% of exercising time (in hours per week) |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORLoïc BIERE, MD PhD
Department of Cardiology, University Hospital of Angers (France)
Outcome results
None listed