Biliary Atresia, Infantile Hepatitis Syndrome, Neonatal Cholestasis
Conditions
Brief summary
Better survival and prognosis of biliary atresia (BA) depend on early diagnosis and timely Kasai portoenterostomy. Identifying BA from other causes of infantile cholestasis at early stage of the disease still remains a major challenge. In this study, the investigators aim to develop and validate a scoring system to screen BA in infants with cholestasis.
Interventions
DIAGNOSTIC_TESTbiliary atresia screen score
The investigators aim to develop a scoring system according to clinical, laboratory, imaging features of biliary atresia in the derivation dataset and tested in the validation datasets.
Sponsors
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 3 Months
Healthy volunteers
Yes
Inclusion criteria
Clinical diagnosis of neonatal cholestasis Age at first visit less than 90 days after birth
Exclusion criteria
Severe congenital malformation Subjects with missing data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Development and Validation a Screening Score for the biliary atresia in infantile cholestasis | 1 weeks | Developed a scoring system according to clinical, laboratory, imaging features of BA and test it in the clinical work. The score system might including clay stool, γ-glutamyl transpeptadase, the results of ultrasound and subscales selected for logistic regression. The total score would sum all the subscales up.The investigators grade the patients with the cholestasis screen score to identify patients with biliary atresia. Patients with score ≤ 15 points considered to be the low-risk group, and patients with risk score \> 15 points considered the high-risk group, and the score model has no maximum or minimum value. |
Countries
China
Contacts
Primary ContactYongjun Zhang, doctor
Outcome results
None listed