Rheumatoid Arthritis
Conditions
Brief summary
MRI has been shown to be helpful in identifying patients who present with undifferentiated inflammatory arthritis who will develop RA within a one year follow up period. The absence of other clinically apparent symptoms often causes delays in diagnosis of RA. The use of the MRI in conjunction with the physical examination has the potential to reduce diagnostic delay. Earlier diagnosis would allow for earlier treatment implementation for better patient outcomes.
Interventions
DIAGNOSTIC_TESTMRI
Magnetic resonance imaging (MRI) produces detailed images of the body's internal structures without relying on radiation. It is used to diagnose and also gauge efficacy of treatment.
Sponsors
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
≥ 18 years old Undifferentiated inflammatory arthritis suspected to be early RA (≥1 joint with synovitis and ≥1 other tender joint) Symptom duration ≤1 year
Exclusion criteria
Unwillingness or inability to return to Mayo Clinic Rochester for research follow-up visits Current or previous use of DMARDS Taking ≥10 mg of prednisone a day Contraindications to contract enhanced MRI History of another definite autoimmune or inflammatory rheumatic disease History of psoriasis History of inflammatory bowel disease Unsuitably as deemed by the principal investigator
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Earlier Diagnosis of RA if MRI is utilized | 1 year | To determine if MRI is predictive of later development of RA in patients with undifferentiated inflammatory arthritis; patients with inflammatory arthritis who receive an MRI will have earlier initiation of treatment |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORKerry Wright, MBBS
Mayo Clinic
Outcome results
None listed