Relationship and Consistency Analysis
Conditions
Brief summary
Breast cancer patients with early breast cancer were enrolled according to the inclusion criteria. Baseline characteristics were recorded from medical record system. Recurrence score were obtained by 21-gene detection kits from different biological companies. Relationship between recurrence score and the prognosis was explored. Meanwhile, the investigators analyzed the consistency of the results obtained from various 21-gene test kits and immunohistochemistry detection.
Interventions
DIAGNOSTIC_TESTrecurrence risk evaluation
Recurrence score were obtained by 21-gene detection kits from different biological companies. The expression of ER, PR, and Her-2 were also detected by IHC.
Sponsors
Xijing Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Inclusion criteria
1. breast cancer in stage I-III, tumor size\>0.5cm 2. lymph nodes negative 3. hormone receptor positive （ER+/PR+,ER+/PR-,ER-/PR+） 4. HER2 negative（IHC 0 or +， FISH negative） 5. receive endocrine therapy only 6. enough FFPE samples within 10 years（3\ 6 10μm ） 7. patients with integrated medical records
Exclusion criteria
1. Tumor cells \<5% 2. Isolated RNA\<500ng
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| correlation analysis | Janyary 1, 2019-December 31, 2019 | x2 value and P value of chi-square test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| consistency analysis | Janyary 1, 2019-December 31, 2019 | kappa value, P value of consistency analysis |
Countries
China
Outcome results
None listed