Study on Prediction of Left Ventricular Remodeling Using ST2

Prediction of ST2 for impRovement of Left ventricUlar Systolic funcTion After Percutaneous Coronary Intervention in Patients With acutE Coronary synDrome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03841214

Acronym

TRUSTED

Enrollment

114

Registered

2019-02-15

Start date

2019-02-25

Completion date

2021-06-30

Last updated

2022-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Coronary Syndrome

Brief summary

Patients who underwent percutaneous coronary intervention after diagnosis of acute coronary syndrome should be enrolled in the study and follow - up.

Detailed description

Obtain written consent for patients who meet all of the selection criteria and who do not meet the exclusion criteria. ACS(Acute Coronary Syndrome) patients with LV systolic dysfunction(LVEF\<50%) on TTE test who underwent successful PCI. At that time, patient proceed with the Baseline blood test(ST2) in hospital. And then, Medical therapy for 3 months later patient proceed with the Follow-up blood test(ST2) and TTE in OPD.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* Subjects aged 19 or older * Patients with acute coronary syndrome who underwent successful percutaneous coronary intervention * Patients with left ventricular ejection fraction less than 50% on transthoracic echocardiography * Patients who voluntarily agreed to participate in the study

Exclusion criteria

* Failure to obtain TIMI 3 flow after procedure * If the remaining life span is less than one year * Women who are breastfeeding or plan to become pregnant or are planning to become pregnant during the study period

Design outcomes

Primary

Measure	Time frame	Description
ST2 and LV end-diastolic volume index	3 months	the correlation between changes of ST2 and LV end-diastolic volume index

Secondary

Measure	Time frame	Description
ST2 and LV ejection fraction	3 months	the correlation between changes of ST2 and LV ejection fraction
ST2 and E over e' ratio	3 months	the correlation between changes of ST2 and E over e' ratio
ST2 and LV wall motion score	3 months	the correlation between changes of ST2 and LV wall motion score

Countries

South Korea

Outcome results