Sjogren's Syndrome
Conditions
Brief summary
Sjogren's syndrome is an autoimmune chronic disease. It has two forms Primary Sjogren's syndrome charactrized by dry eyes and dry mouth. Secondary Sjogren's syndrome characterized by rheumatoid diseases as rheumatoid arthritis, scleroderma and lupus erythematosus. SS patients are most liable to oral candidiasis , so they need prophylaxis aganist oral candidiasis. Probiotic bacteria are live microorganisms that when administered in adequate amounts confer benefits to health.Probiotics are commonly used as a prophylaxis aganist oral candidosis.
Interventions
DRUGProbiotic Product - Cap
probiotic capsule complex composed of L.acidophilus, L. bulgaricus, Streptococcus thermophilus, and Bifidobacterium bifidus
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* primary or scondary Sjogren's syndrome
Exclusion criteria
* allergy to milk derivatives previous intake of antifungals
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain assessment | 5 WEEKS | Numerical Rating Scale ( NRS) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Candidal load | 5 weeks | colony forming unit CFU/ml |
Countries
Egypt
Outcome results
None listed