Diabetes, Hepatitis C, Acute, Hypertension
Conditions
Brief summary
An observational double-blind cohort study that examined the association between HCV viral hepatitis, blood sugar level and systolic blood pressure in the Egyptian population
Detailed description
a cohort study on greater than 70000 Egyptian patients had been conducted. for all patients,1- we detected the Hepatitis C Virus (HCV) RNA antigens ( hepatitis C virus)presence using BIOLINE HCV kits( qualitative test for diagnosis of hepatitis C virus in the blood), For all positive patients, confirmatory rapid screening test was performed and all patients who tested positive twice underwent a qPCR test using QIAampMinElute Virus Spin kit (Thermo Fisher Scientific, Waltham, MA, USA) performed according to the manufacturer's recommended protocol. 2- Investigators measured blood sugar levels for each patient using ACCU-CHEK kits(finger stick sugar level measurement) 3- Measured systolic blood pressure for each patient was measured using mercury meters. 4-for all patients investigators obtained full medical history regarding the presence or absence of chronic diabetes, chronic hypertension, coronary artery disease, kidney impairment with dialysis or chronic obstructive pulmonary disease. 5- for all patients investigators listed age, gender, and body mass index. 66121 patients were negative for HCV and 4852 were positive for HCV. Investigators measured the association between HCV presence, high blood sugar levels and high systolic blood pressure. It is supposed that this is the largest study in the world that examined both associations. In a word, this study was responding to a specific question: is hepatitis c virus presence is associated with high blood pressure or high sugar level or both or not associated???
Interventions
DIAGNOSTIC_TESTBIOLINE HCV kits
We used BIOLINE HCV kits to detect the presence of HCV antibodies in stick blood samples of all recruited patients.
DIAGNOSTIC_TESTACCU-CHEK kits
For all patients, we measured random blood sugar levels by stick blood samples using ACCU-CHEK kits.
DIAGNOSTIC_TESTErKameter 3000 mercury manometer
For all patients, we measured systolic blood pressure using ErKameter 3000 mercury manometer.
Sponsors
Cairo University
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Egyptian citizens from 18 years to 80 years.
Exclusion criteria
* Patients younger than 18 years or older than 80 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| HCV diagnosis | 20 minutes | Detection of patients who are HCV positive or negative |
| Measurement of blood sugar level in mg/dl | 1 minute | Detection of the percentage of patients with high blood sugar level in HCV positive or negative patients |
| Measurement of systolic blood pressure in mmHg | 1 minute | Detection of the percentage of patients with high systolic blood pressure in HCV positive or negative patients |
Countries
Egypt
Outcome results
None listed