Short Term Refractive and Ocular Parameter Changes After Topical Atropine

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03839888

Enrollment

Registered

2019-02-15

Start date

2015-01-01

Completion date

2015-12-31

Last updated

2019-02-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myopia, Left Eye

Keywords

atropine, cycloplegia, refraction, axial length, anterior chamber depth

Brief summary

In order we had designed a prospective clinical trial. Spherical equivalent refractive error (SER), axial length (AL), mean keratometric value (Mean-K), anterior chamber depth (ACD), and intraocular pressure (IOP) were measured at baseline and one week after topical use of 0.125% atropine. Postcycloplegic changes of refractive error and ocular parameters were evaluated, and their correlations were analyzed with multiple linear regression models.

Interventions

DRUG0.125% Atropine

patients used 0.125% atropine eyedrop per night before sleep for 7 days.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

3 Years to 18 Years

Healthy volunteers

Inclusion criteria

* Patients who had an SER of -0.5 diopters or less in their eyes.

Exclusion criteria

* Patients who had already been undergoing cycloplegic treatment for myopia before.

Design outcomes

Primary

Measure	Time frame	Description
SER	change from SER at 7 days	Spherical equivalent refractive error

Secondary

Measure	Time frame	Description
AL	change from AL at 7 days	Axial length
ACD	change from ACD at 7 days	anterior chamber depth
IOP	change from IOP at 7 days	intraocular pressure

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 22, 2026