Healthy, Stroke, Ischemic
Conditions
Keywords
stochastic resonance, proprioception, motor control, motor recovery
Brief summary
This study evaluates the effectiveness of stochastic resonance electric stimulation on neuromuscular control and proprioception in healthy and individuals with stroke.
Detailed description
Stroke is one of the leading causes of motor disability. The main intervention strategy in stroke rehabilitation is to induce cortical plasticity for motor re-learning. It has been demonstrated that electrical stimulation applied to the periphery can elicit abundant sensory afferent inputs to enhance excitability and activation area in the sensorimotor cortex. Recent evidence suggested that a new type of electrical stimulation pattern, stochastic resonance stimulation, is capable of efficiently enhancing the activation of peripheral and central nervous system. Therefore, the purpose of this study are to identify the effects of stochastic resonance electrical stimulation on neuromuscular control and proprioception, and to investigate the effectiveness of combining stochastic resonance electrical stimulation with rehabilitation program on post stroke motor function recovery.
Interventions
OTHERstochastic resonance electrical stimulation
stochastic resonance electrical stimulation is applied in the upper extremity during motor functional training. Sham comparator group uses sham stimulation - same electrode location, but no electrical current is applied during motor functional training
Sponsors
Taipei Veterans General Hospital, Taiwan
National Yang Ming Chiao Tung University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
In first stage Inclusion Criteria: healthy adults without history of neurological disorders or limitation in range of motion for thumb flexion In the second stage Inclusion Criteria: 1. first-ever cerebral cortical region involved chronic stroke, onset over a month 2. able to perform active grasp on the affected side with the scores of manual muscle test at least two points 3. at stable medical condition for intervention confirmed by a specialized physician. The
Exclusion criteria
were 1. history of other neurological disorders 2. cognitive impairment (Mini-Mental State Examination score \< 24, MMSE)29 3. unable to follow instructions 4. contraindications of ES 5. under 20 years old.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EEG | baseline and one minute after stimulation | we will calculate power spectral and see whether change in the alpha, beta, theta band |
| Fugl-Meyer Assessment for Upper Extremity | baseline and one minute after stimulation | changes in upper extremity function of the stroke subjects |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| force deviation | baseline and one minute after stimulation | we first calculated the absolute value of the difference between force output and the value of 50%MVC for each data point and then calculated the average force deviation value by dividing the sum of all values by the number of data points |
| joint angle | baseline and one minute after stimulation | ABS(the subject perform degree - target degree ) |
| muscle activation | baseline and one minute after stimulation | EMG changes in stimulation |
Countries
Taiwan
Contacts
Primary ContactLi-Wei Chou, PhD
Backup ContactShiang-Lin Hou
Outcome results
None listed