Anesthesia; Adverse Effect, Anesthesia; Reaction, Cognitive Change, Cognitive Decline, Cognitive Impairment, Postoperative Delirium
Conditions
Brief summary
The research team is creating a foundational infrastructure in order to develop a precision medicine approach for geriatric patients who require surgery with anesthesia. The team plans to build the first of its kind comprehensive database of demographic and risk factor questionnaire responses, biobanked blood specimens, intraoperative electroencephalography (EEG), and inclusive cognitive testing throughout patient interaction starting at the preop appointment until a year later. This will be used to create a predictive model of periooperative neurocognitive disorders.
Interventions
COMBINATION_PRODUCTNeurocognition Interventions
EEG, Neurocognitive Battery Testing, and Immune Profiles
Sponsors
Stanford University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* At least 65 years old (inclusive) * Non cardiac general elective surgery * General anesthesia is expected for 2+ hours
Exclusion criteria
* Alzheimer's * Dementia * Parkinson's * History of neurodegenerative diseases * Medication for depression (ie. Benzodiazepines) * Alcoholism * Discretion of PI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Neurocognitive Disorders | 3 years | Neurocognitive Assessment Battery |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORDavid Drover, MD
Stanford University
Outcome results
None listed