Fall, Mild Cognitive Impairment
Conditions
Keywords
gait, computerized cognitive training, falls, mild cognitive impairment, mobility, physical exercise, tai chi chuan
Brief summary
A single-blinded, randomized controlled trial is designed to compare the effects of social interaction, computerized cognitive training, lower extremity strengthening, and tai chi chuan on improving cognitive functions and gait/mobility and reducing falls among 228 subjects with mild cognitive impairment, in which the influence of adherence to the intervention programs will also be examined.
Interventions
BEHAVIORALExercise
Each session will last 60 min, consisting of 10 min of warm-up, 45 min of exercise, and a 5-min cool-down.
BEHAVIORALComputerized training
Attention, memory, speed of processing, and executive functioning.
Sponsors
Ministry of Science and Technology, Taiwan
Taipei Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Intervention model description
A single-blinded, randomized controlled trial is designed to compare the effects of social interaction, computerized cognitive training, lower extremity strengthening, and tai chi chuan on improving cognitive functions and gait/mobility and reducing falls.
Eligibility
Sex/Gender
ALL
Age
65 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* At least 65 years old * Had a fall at least 3 months prior to the baseline assessment * Can ambulate independently * Has mild cognitive impairment
Exclusion criteria
* Cannot ambulate independently and communicate with researchers * Have a major unstable cardiopulmonary disease (e.g., ischemic chest pain, shortness of breath, recurrent syncopal episodes, orthopnea, paroxysmal nocturnal dyspnea, palpitations, or tachycardia) * Have a contraindication to physical exercise (e.g., severe osteoarthritis or severe pulmonary hypertension)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| falls | 12 months | number of falls and multiple falls |
| modified Telephone Interview of Cognitive Status (TICS-M) | 12 months | The modified Telephone Interview of Cognitive Status (TICS-M) consists of the date of the interview, age, phone number, immediate and delayed word list recall, counting backward, responsive naming, word opposites, and repetition, with a total score range of 0\ 50. |
| mobility | 12 months | The timed up and go test requires subjects to rise from a standard chair, walk a distance of 3 m, turn, walk back to the chair, and sit down. The time to complete the timed up and go will be recorded. |
| balance | 12 months | The Tinetti balance score ranges 0\ 26, with a higher score indicating a better balance ability. |
| Mattis Dementia Rating Scale (MDRS) | 12 months | The Mattis Dementia Rating Scale (MDRS) contains five cognitive domains of attention, initiation/perseveration, construction, conceptualization, and memory, which specifically assess concentration, verbal fluency, visuospatial skills, analogical reasoning, and short-term memory, with score ranges for these domains of 0\ 37, 0\ 37, 0\ 6, 0\ 39, and 0\ 25 points, respectively, and a total score range of 0\ 144 points. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| fear of falling | 12 months | Activities-specific Balance Confidence (ABC) scale assesses an individual's confidence in performing 16 common daily tasks without losing balance, and total scores of the ABC scale are determined by the accumulated average of each item score and range between 0 and 100, with lower scores indicating greater balance confidence. |
| activity of daily living (ADL) | 12 months | The activity of daily living (ADL) scale consists of seven basic ADLs (self-feeding, self-dressing, grooming, walking, getting in/out of bed, bathing, and controlling the bladder) and seven instrumental ADLs (using a telephone, transporting oneself, shopping, preparing meals, doing housework, taking medication, and managing one's money). These items are graded as 0 points (inability), 1 point (needs some help), or 2 points (no help needed). The ADL score ranges from 0 to 28 points, with a lower score indicating greater activity disability. |
| depressive symptoms | 12 months | Depressive symptoms will be assessed using the 15-item Geriatric Depression Scale. |
Countries
Taiwan
Contacts
Primary ContactMau-Roung Lin, Professor
Outcome results
None listed