Liver Cirrhoses
Conditions
Brief summary
All consenting, adult patients aged 18 years and above who will require elective ventilation after liver transplant recipient surgery will be enrolled for the study. Patients in acute liver failure, hepatic encephalopathy or patients with history of allergic reactions to propofol will be excluded from the study. This is an observational study. As per institute treatment protocol, propofol will be given post-operatively at a dose of 1 mg/kg/hr and than titrated to maintain a Bi-Spectral Index (BIS) score of 60-80 till the patient is on ventilator. There will be no deviation from our routine institutional protocol and no other sedative drugs like opioids or benzodiazepines will be used and no interventions will be done. Hemodynamics will be maintained targeting a mean arterial pressure (MAP) of at least 65 mm Hg. during the study period using appropriate measures.
Interventions
None listed
Sponsors
Institute of Liver and Biliary Sciences, India
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
• Living donor liver transplant (LDLT) recipient adult patients ≥ 18 years of age requiring postoperative elective ventilation.
Exclusion criteria
* Propofol allergy * Acute liver failure (ALF). * Hepatic encephalopathy (HE)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dosage of propofol in mg/kg/hr required for sedation (BIS:60-80) of postoperative electively ventilated living donor liver transplant recipients. | up to 24 hours | Every 2 hrly , the continuous intravenous Propofol dose going on will be recorded. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes of propofol dose over the study period to maintain BIS between 60 -80 | up to 24 hours | Propofol doses will be recorded titrated to BIS of 60-80 |
| Correlation of the mean dose of propofol in mg/kg/hr with Arterial ammonia at baseline and to see the association between immediate post operative and Postoperative day1 ammonia with corresponding propofol dose. | up to 24 hours | Arterial ammonia levels will be noted pre-operatively, immediate post-operative and after extubation. |
| Correlation of propofol dose with respective arterial lactate levels every 2 hours during the period of elective ventilation | up to 24 hours | Lactate levels will be recorded every 2 hrs till the patient is on ventilator |
Countries
India
Contacts
Primary ContactRishabh jaju, DNB
Backup ContactKelika Prakash, DM
Outcome results
None listed