Crohn Disease, Inflammatory Bowel Diseases, Ulcerative Colitis
Conditions
Brief summary
Ulcerative colitis and Crohn's disease are the commonest types of inflammatory bowel disease (IBD). Both conditions range in severity from no symptoms to being potentially fatal. Both conditions are treated with medications which suppress the immune system. It is not known whether this increases the risk for infections and cancers in these conditions. It is also recognised by healthcare professionals that these conditions cause a considerable amount of psychological distress. However, this has never been measured in a large population sample. This study will investigate any associations with treatment and new onset infections and cancer. They will also examine the relationship between IBD and common mental health problems (specifically, depression and anxiety) and the impact that these have on the healthcare use (including number of general practitioner \[GP\] appointments, hospital attendances, and medication prescriptions. Combined, these studies should provide a better understanding of the impact of IBD on affected people and provide evidence to support the correct allocation of healthcare resources.
Detailed description
Objective We aim to provide an accurate and contemporary measurement of the current healthcare resource utilisation in people with inflammatory bowel disease (IBD); namely ulcerative colitis (UC) and Crohn's disease (CD). We also aim to provide estimates of infection incidence in this population and the prevalence of common mental health conditions. Method We will identify UC and CD using algorithms validated for accurately identifying these conditions from primary care records in the United Kingdom (UK). We will identify a prevalent cohort of adults with IBD with the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) network over the last decade. We will identify a matched cohort of people without IBD; matched on age, gender and primary care practice. Across these cohorts we will compare healthcare resource utilisation (primary care attendances, number of primary care prescriptions for antidepressant and anxiolytic medications, number of primary care prescriptions for medications used in IBD, recorded secondary care attendances, and issue of statements of fitness for work), incident infections (any common infection, any viral infection, or any gastrointestinal infection), and common mental health conditions (depression and anxiety).
Interventions
OTHERNo intervention
Observation of routine clinical practice
Sponsors
Pfizer
University of Surrey
Momentum Data
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients aged ≥18 years over the study period * Registered with a contributing primary care practice for any duration during the study period
Exclusion criteria
* IBD not classifiable or of a type other than UC or Crohn's disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Measured over 5 years - 2014 to 2019 inclusive | Sub-infection outcomes: URTI, Pneumonia, Acute Bronchitis, Influenza, Skin infection, Genital infection, UTI, GI infection subset (only stool culture confirmed Clostridium difficile, Salmonella, Shigella, and Campylobacter infections), Herpes Simplex infection, Herpes Zoster infection |
| Prevalence of Anxiety Episodes (Ulcerative Colitis) | Measured over five years - 2014 to 2018 inclusive | Compare the prevalence of anxiety episodes in people with and without Ulcerative Colitis. Number of people with at least one anxiety episode |
| Prevalence of Depressive Episodes (Crohn's Disease) | Measured over five years - 2014 to 2018 inclusive | Compare the prevalence of depressive episodes in people with and without Crohn's disease. Number of people with at least one depressive episode |
| Number of People With at Least One Infection Event in Those With and Without Ulcerative Colitis | Measured over 5 years - 2014 to 2018 inclusive | Number of people with at least one infection event during follow up for any common infection, gastrointestinal infection, and any viral infection. |
| Number of People With at Least One Infection Event in Those With and Without Crohn's Disease | Measured over 5 years - 2014 to 2019 inclusive | Number of people with at least one infection event during follow up for any common infection, gastrointestinal infection, and any viral infection. |
| Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Measured over 5 years - 2014 to 2019 inclusive | Sub-infection outcomes: Upper respiratory tract infection (URTI), Pneumonia, Acute Bronchitis, Influenza, Skin infection, Genital infection, urinary tract infection (UTI), GI infection subset (only stool culture confirmed Clostridium difficile, Salmonella, Shigella, and Campylobacter infections), Herpes Simplex infection, Herpes Zoster infection |
| Prevalence of Depressive Episodes (Ulcerative Colitis) | Measured over five years - 2014 to 2018 inclusive | Compare the prevalence of depressive episodes in people with and without Ulcerative Colitis. Number of people with at least one depressive episode. |
| Number of People With Depressive Disorder in People With and Without Crohn's Disease | Measured over five years - 2014 to 2018 inclusive | Compare the prevalence of depressive disorder in people with and without Crohn's disease. |
| Number of People With Depressive Disorder in People With and Without Ulcerative Colitis | Measured over five years - 2014 to 2018 inclusive | Compare the prevalence of depressive disorder in people with and without Ulcerative Colitis. |
| Prevalence of Anxiety Episodes (Crohn's Disease) | Measured over five years - 2014 to 2018 inclusive | Compare the prevalence of anxiety episodes in people with and without Crohn's disease. Number of people with at least one anxiety episode in people. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Healthcare Resource Utilization - Secondary Care Emergency Attendances | Measured over five years - 2014 to 2018 inclusive | Compare healthcare resource utilization in people with and without IBD, and stratifying by IBD type and compare healthcare resource utilization in people with IBD, with and without mental health illness. |
| Healthcare Resource Utilization - Fitness for Work Notes | Measured over five years - 2014 to 2018 inclusive | Compare healthcare resource utilization in people with and without IBD, and stratifying by IBD type and compare healthcare resource utilization in people with IBD, with and without mental health illness. |
| Healthcare Resource Utilization: Medications for Mental Health Conditions - Selective Serotonin Reuptake Inhibitors (SSRIs) | Measured over five years - 2014 to 2018 inclusive | Compare healthcare resource utilization in people with and without IBD, and stratifying by IBD type and compare healthcare resource utilization in people with IBD, with and without mental health illness. |
| Healthcare Resource Utilization: Medications for Mental Health Conditions - Anxiolytic Medications | Measured over five years - 2014 to 2018 inclusive | Compare healthcare resource utilization in people with and without IBD, and stratifying by IBD type and compare healthcare resource utilization in people with IBD, with and without mental health illness. |
| Healthcare Resource Utilization - Primary Care Visits | Measured over five years - 2014 to 2018 inclusive | Compare healthcare resource utilization in people with and without IBD, and stratifying by IBD type and compare healthcare resource utilization in people with IBD, with and without mental health illness. |
Countries
United Kingdom
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| People With Inflammatory Bowel Disease (Cases) Adults (18+) with inflammatory bowel disease registered with a contributing GP practice during the study period
No intervention: Observation of routine clinical practice | 19,011 |
| People Without Inflammatory Bowel Disease (Controls) Adults (18+) without inflammatory bowel disease registered with a contributing GP practice during the study period
No intervention: Observation of routine clinical practice | 76,044 |
| Total | 95,055 |
Baseline characteristics
| Characteristic | People With Inflammatory Bowel Disease (Cases) | People Without Inflammatory Bowel Disease (Controls) | Total |
|---|---|---|---|
| Age, Customized 18-29 | 2276 Participants | 9416 Participants | 11692 Participants |
| Age, Customized 30-39 | 3036 Participants | 11931 Participants | 14967 Participants |
| Age, Customized 40-49 | 3379 Participants | 13593 Participants | 16972 Participants |
| Age, Customized 50-59 | 3560 Participants | 14305 Participants | 17865 Participants |
| Age, Customized 60-69 | 3235 Participants | 12890 Participants | 16125 Participants |
| Age, Customized 70-79 | 2278 Participants | 8942 Participants | 11220 Participants |
| Age, Customized 80+ | 1247 Participants | 4967 Participants | 6214 Participants |
| BMI Normal weight (18.5-25) | 639 Participants | 1814 Participants | 2453 Participants |
| BMI Not recorded | 1544 Participants | 8454 Participants | 9998 Participants |
| BMI Obese (≥30) | 3775 Participants | 17379 Participants | 21154 Participants |
| BMI Overweight (25-30) | 5824 Participants | 23707 Participants | 29531 Participants |
| BMI Underweight (≤18.5) | 7229 Participants | 24690 Participants | 31919 Participants |
| Comorbidities - Angina | 606 Participants | 2075 Participants | 2681 Participants |
| Comorbidities - Asthma | 3796 Participants | 12924 Participants | 16720 Participants |
| Comorbidities - Atrial fibrillation | 658 Participants | 2336 Participants | 2994 Participants |
| Comorbidities - Chronic liver disease | 386 Participants | 487 Participants | 873 Participants |
| Comorbidities - Chronic Obstructive Pulmonary Disease (COPD) | 982 Participants | 2990 Participants | 3972 Participants |
| Comorbidities - Dementia | 694 Participants | 2786 Participants | 3480 Participants |
| Comorbidities - Heart failure | 296 Participants | 1062 Participants | 1358 Participants |
| Comorbidities - Hypertension | 4249 Participants | 17591 Participants | 21840 Participants |
| Comorbidities - Myocardial infarction | 481 Participants | 1650 Participants | 2131 Participants |
| Comorbidities - Rheumatoid arthritis | 281 Participants | 706 Participants | 987 Participants |
| Comorbidities - Stroke | 387 Participants | 1382 Participants | 1769 Participants |
| Comorbidities - Type 2 diabetes | 1665 Participants | 6336 Participants | 8001 Participants |
| Index of Multiple Deprivation (IMD) quintile 1 (most deprived) | 2396 Participants | 9933 Participants | 12329 Participants |
| Index of Multiple Deprivation (IMD) quintile 2 | 2846 Participants | 11514 Participants | 14360 Participants |
| Index of Multiple Deprivation (IMD) quintile 3 | 3617 Participants | 14720 Participants | 18337 Participants |
| Index of Multiple Deprivation (IMD) quintile 4 | 4684 Participants | 18137 Participants | 22821 Participants |
| Index of Multiple Deprivation (IMD) quintile 5 (least deprived) | 5117 Participants | 20388 Participants | 25505 Participants |
| Index of Multiple Deprivation (IMD) quintile Not recorded | 351 Participants | 1352 Participants | 1703 Participants |
| Race and Ethnicity Not Collected | — | — | 0 Participants |
| Region of Enrollment United Kingdom | 19011 participants | 76044 participants | 95055 participants |
| Sex: Female, Male Female | 9968 Participants | 39746 Participants | 49714 Participants |
| Sex: Female, Male Male | 9043 Participants | 36298 Participants | 45341 Participants |
| Use of systemic therapy | 4183 Participants | 700 Participants | 4883 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 0 | 0 / 0 |
| other Total, other adverse events | 0 / 0 | 0 / 0 |
| serious Total, serious adverse events | 0 / 0 | 0 / 0 |
Outcome results
Primary
Number of People With at Least One Infection Event in Those With and Without Crohn's Disease
Number of people with at least one infection event during follow up for any common infection, gastrointestinal infection, and any viral infection.
Time frame: Measured over 5 years - 2014 to 2019 inclusive
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| People With Crohn's Disease (Cases) | Number of People With at Least One Infection Event in Those With and Without Crohn's Disease | Any common infection | 3470 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Infection Event in Those With and Without Crohn's Disease | Gastrointestinal infection | 395 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Infection Event in Those With and Without Crohn's Disease | Viral infection | 1797 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Infection Event in Those With and Without Crohn's Disease | Any common infection | 11227 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Infection Event in Those With and Without Crohn's Disease | Gastrointestinal infection | 841 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Infection Event in Those With and Without Crohn's Disease | Viral infection | 5917 Participants |
Primary
Number of People With at Least One Infection Event in Those With and Without Ulcerative Colitis
Number of people with at least one infection event during follow up for any common infection, gastrointestinal infection, and any viral infection.
Time frame: Measured over 5 years - 2014 to 2018 inclusive
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| People With Crohn's Disease (Cases) | Number of People With at Least One Infection Event in Those With and Without Ulcerative Colitis | Viral infection | 2544 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Infection Event in Those With and Without Ulcerative Colitis | Any common infection | 5111 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Infection Event in Those With and Without Ulcerative Colitis | Gastrointestinal infection | 510 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Infection Event in Those With and Without Ulcerative Colitis | Viral infection | 8510 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Infection Event in Those With and Without Ulcerative Colitis | Any common infection | 17403 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Infection Event in Those With and Without Ulcerative Colitis | Gastrointestinal infection | 1365 Participants |
Primary
Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease
Sub-infection outcomes: URTI, Pneumonia, Acute Bronchitis, Influenza, Skin infection, Genital infection, UTI, GI infection subset (only stool culture confirmed Clostridium difficile, Salmonella, Shigella, and Campylobacter infections), Herpes Simplex infection, Herpes Zoster infection
Time frame: Measured over 5 years - 2014 to 2019 inclusive
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | URTI | 1475 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Pneumonia | 59 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Acute Bronchitis | 1059 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Influenza | 158 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Skin infections | 1201 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Genital infection | 219 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | UTI | 473 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | GI infection subset | 76 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Herpes Simplex infection | 109 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Herpes Zoster infection | 237 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | GI infection subset | 130 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | URTI | 5002 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Genital infection | 665 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Pneumonia | 136 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Herpes Zoster infection | 491 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Acute Bronchitis | 3211 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | UTI | 1568 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Influenza | 621 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Herpes Simplex infection | 253 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Crohn's Disease | Skin infections | 3294 Participants |
Primary
Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis
Sub-infection outcomes: Upper respiratory tract infection (URTI), Pneumonia, Acute Bronchitis, Influenza, Skin infection, Genital infection, urinary tract infection (UTI), GI infection subset (only stool culture confirmed Clostridium difficile, Salmonella, Shigella, and Campylobacter infections), Herpes Simplex infection, Herpes Zoster infection
Time frame: Measured over 5 years - 2014 to 2019 inclusive
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | URTI | 2118 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Pneumonia | 100 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Acute Bronchitis | 1754 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Influenza | 234 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Skin infections | 1654 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | UTI | 733 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | GI infection subset | 121 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Herpes Simplex infection | 106 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Herpes Zoster infection | 309 Participants |
| People With Crohn's Disease (Cases) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Genital infection | 246 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Genital infection | 874 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | URTI | 7143 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Herpes Zoster infection | 839 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Pneumonia | 288 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | UTI | 2631 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Acute Bronchitis | 5554 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Herpes Simplex infection | 352 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Influenza | 856 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | GI infection subset | 198 Participants |
| People Without Crohn's Disease (Controls) | Number of People With at Least One Sub-infection Event in Those With and Without Ulcerative Colitis | Skin infections | 5268 Participants |
Primary
Number of People With Depressive Disorder in People With and Without Crohn's Disease
Compare the prevalence of depressive disorder in people with and without Crohn's disease.
Time frame: Measured over five years - 2014 to 2018 inclusive
Population: Subset of people diagnosed with IBD having Crohn's disease
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| People With Crohn's Disease (Cases) | Number of People With Depressive Disorder in People With and Without Crohn's Disease | 1322 Participants |
| People Without Crohn's Disease (Controls) | Number of People With Depressive Disorder in People With and Without Crohn's Disease | 3911 Participants |
Primary
Number of People With Depressive Disorder in People With and Without Ulcerative Colitis
Compare the prevalence of depressive disorder in people with and without Ulcerative Colitis.
Time frame: Measured over five years - 2014 to 2018 inclusive
Population: Subset of people diagnosed with IBD having Ulcerative colitis
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| People With Crohn's Disease (Cases) | Number of People With Depressive Disorder in People With and Without Ulcerative Colitis | 1627 Participants |
| People Without Crohn's Disease (Controls) | Number of People With Depressive Disorder in People With and Without Ulcerative Colitis | 5676 Participants |
Primary
Prevalence of Anxiety Episodes (Crohn's Disease)
Compare the prevalence of anxiety episodes in people with and without Crohn's disease. Number of people with at least one anxiety episode in people.
Time frame: Measured over five years - 2014 to 2018 inclusive
Population: Subset of people diagnosed with IBD having Crohn's disease
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| People With Crohn's Disease (Cases) | Prevalence of Anxiety Episodes (Crohn's Disease) | 262 Participants |
| People Without Crohn's Disease (Controls) | Prevalence of Anxiety Episodes (Crohn's Disease) | 892 Participants |
Primary
Prevalence of Anxiety Episodes (Ulcerative Colitis)
Compare the prevalence of anxiety episodes in people with and without Ulcerative Colitis. Number of people with at least one anxiety episode
Time frame: Measured over five years - 2014 to 2018 inclusive
Population: Subset of people diagnosed with IBD having Ulcerative Colitis
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| People With Crohn's Disease (Cases) | Prevalence of Anxiety Episodes (Ulcerative Colitis) | 341 Participants |
| People Without Crohn's Disease (Controls) | Prevalence of Anxiety Episodes (Ulcerative Colitis) | 1221 Participants |
Primary
Prevalence of Depressive Episodes (Crohn's Disease)
Compare the prevalence of depressive episodes in people with and without Crohn's disease. Number of people with at least one depressive episode
Time frame: Measured over five years - 2014 to 2018 inclusive
Population: Subset of people diagnosed with IBD having Crohn's disease
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| People With Crohn's Disease (Cases) | Prevalence of Depressive Episodes (Crohn's Disease) | 431 Participants |
| People Without Crohn's Disease (Controls) | Prevalence of Depressive Episodes (Crohn's Disease) | 1233 Participants |
Primary
Prevalence of Depressive Episodes (Ulcerative Colitis)
Compare the prevalence of depressive episodes in people with and without Ulcerative Colitis. Number of people with at least one depressive episode.
Time frame: Measured over five years - 2014 to 2018 inclusive
Population: Subset of people diagnosed with IBD having Ulcerative Colitis
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| People With Crohn's Disease (Cases) | Prevalence of Depressive Episodes (Ulcerative Colitis) | 507 Participants |
| People Without Crohn's Disease (Controls) | Prevalence of Depressive Episodes (Ulcerative Colitis) | 1666 Participants |
Secondary
Healthcare Resource Utilization - Fitness for Work Notes
Compare healthcare resource utilization in people with and without IBD, and stratifying by IBD type and compare healthcare resource utilization in people with IBD, with and without mental health illness.
Time frame: Measured over five years - 2014 to 2018 inclusive
Population: The arm/Groups titled people with ulcerative colitis and people with Crohn's disease are subsets of the arm/Group titled people with IBD
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| People With Crohn's Disease (Cases) | Healthcare Resource Utilization - Fitness for Work Notes | 0.311 Notes issued per person per year |
| People Without Crohn's Disease (Controls) | Healthcare Resource Utilization - Fitness for Work Notes | 0.270 Notes issued per person per year |
| People With Crohn's Disease | Healthcare Resource Utilization - Fitness for Work Notes | 0.378 Notes issued per person per year |
| People Without IBD | Healthcare Resource Utilization - Fitness for Work Notes | 0.215 Notes issued per person per year |
Secondary
Healthcare Resource Utilization: Medications for Mental Health Conditions - Anxiolytic Medications
Compare healthcare resource utilization in people with and without IBD, and stratifying by IBD type and compare healthcare resource utilization in people with IBD, with and without mental health illness.
Time frame: Measured over five years - 2014 to 2018 inclusive
Population: The arm/Groups titled people with ulcerative colitis and people with Crohn's disease are subsets of the arm/Group titled people with IBD
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| People With Crohn's Disease (Cases) | Healthcare Resource Utilization: Medications for Mental Health Conditions - Anxiolytic Medications | 0.219 Prescriptions per person per year |
| People Without Crohn's Disease (Controls) | Healthcare Resource Utilization: Medications for Mental Health Conditions - Anxiolytic Medications | 0.189 Prescriptions per person per year |
| People With Crohn's Disease | Healthcare Resource Utilization: Medications for Mental Health Conditions - Anxiolytic Medications | 0.264 Prescriptions per person per year |
| People Without IBD | Healthcare Resource Utilization: Medications for Mental Health Conditions - Anxiolytic Medications | 0.166 Prescriptions per person per year |
Secondary
Healthcare Resource Utilization: Medications for Mental Health Conditions - Selective Serotonin Reuptake Inhibitors (SSRIs)
Compare healthcare resource utilization in people with and without IBD, and stratifying by IBD type and compare healthcare resource utilization in people with IBD, with and without mental health illness.
Time frame: Measured over five years - 2014 to 2018 inclusive
Population: The arm/Groups titled people with ulcerative colitis and people with Crohn's disease are subsets of the arm/Group titled people with IBD
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| People With Crohn's Disease (Cases) | Healthcare Resource Utilization: Medications for Mental Health Conditions - Selective Serotonin Reuptake Inhibitors (SSRIs) | 1.328 Prescriptions per person per year |
| People Without Crohn's Disease (Controls) | Healthcare Resource Utilization: Medications for Mental Health Conditions - Selective Serotonin Reuptake Inhibitors (SSRIs) | 1.218 Prescriptions per person per year |
| People With Crohn's Disease | Healthcare Resource Utilization: Medications for Mental Health Conditions - Selective Serotonin Reuptake Inhibitors (SSRIs) | 1.495 Prescriptions per person per year |
| People Without IBD | Healthcare Resource Utilization: Medications for Mental Health Conditions - Selective Serotonin Reuptake Inhibitors (SSRIs) | 1.046 Prescriptions per person per year |
Secondary
Healthcare Resource Utilization - Primary Care Visits
Compare healthcare resource utilization in people with and without IBD, and stratifying by IBD type and compare healthcare resource utilization in people with IBD, with and without mental health illness.
Time frame: Measured over five years - 2014 to 2018 inclusive
Population: The arm/Groups titled people with ulcerative colitis and people with Crohn's disease are subsets of the arm/Group titled people with IBD
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| People With Crohn's Disease (Cases) | Healthcare Resource Utilization - Primary Care Visits | 6.41 Visits per person per year |
| People Without Crohn's Disease (Controls) | Healthcare Resource Utilization - Primary Care Visits | 6.18 Visits per person per year |
| People With Crohn's Disease | Healthcare Resource Utilization - Primary Care Visits | 6.78 Visits per person per year |
| People Without IBD | Healthcare Resource Utilization - Primary Care Visits | 4.49 Visits per person per year |
Secondary
Healthcare Resource Utilization - Secondary Care Emergency Attendances
Compare healthcare resource utilization in people with and without IBD, and stratifying by IBD type and compare healthcare resource utilization in people with IBD, with and without mental health illness.
Time frame: Measured over five years - 2014 to 2018 inclusive
Population: The arm/Groups titled people with ulcerative colitis and people with Crohn's disease are subsets of the arm/Group titled people with IBD
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| People With Crohn's Disease (Cases) | Healthcare Resource Utilization - Secondary Care Emergency Attendances | 0.455 Attendances per person per year |
| People Without Crohn's Disease (Controls) | Healthcare Resource Utilization - Secondary Care Emergency Attendances | 0.396 Attendances per person per year |
| People With Crohn's Disease | Healthcare Resource Utilization - Secondary Care Emergency Attendances | 0.546 Attendances per person per year |
| People Without IBD | Healthcare Resource Utilization - Secondary Care Emergency Attendances | 0.259 Attendances per person per year |