Analysis of the Impact of Cholecystectomy on Gut Microbiome in Adults

Analysis by High-throughput Sequencing: the Impact of Cholecystectomy on Gut Microbiome in Adults

Status

UNKNOWN

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03836170

Enrollment

Registered

2019-02-11

Start date

2018-05-15

Completion date

2019-06-01

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic Cholecystectomy

Keywords

laparoscopic cholecystectomy, gut microbiota

Brief summary

Laparoscopic cholecystectomy (LC) is widely used in the gallbladder stone, gallbladder polyp, gallbladder cancer and other diseases. Some of the patients would develop diarrhea after surgery, and studies have reported an increased risk of colorectal cancer after LC. The aim of the present study was to examine the effects of LC on the gut microbiota.

Interventions

PROCEDURELaparoscopic cholecystectomy

A special catheter was inserted into the peritoneal cavity, and then about 2-5 liters of carbon dioxide was injected. After reaching a certain pressure, four small holes of 0.5-1.5cm were opened in the abdomen to dissect the structure of the triangle of the gallbladder. The gallbladder duct and gallbladder artery were cut off and closed, and then the entire gallbladder was removed.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

1. Gallbladder polyps diameter mm \>10; 2. The history of the symptoms of patients with gallbladder stones, there was no history of acute attack in the past month; 3. Age \<70 years old; 4. No serious systemic diseases such as diabetes, hypertension, heart disease, lung disease and so on/American anesthesia Association (ASA) grade I or II; 5. BMI\<30; 6. Families have better care and observation, and away from the hospital within 1 hours; patients and their families understand the process of ambulatory surgery (24 hours) and the pros and cons.

Exclusion criteria

1. Less than 18 years old; 2. With previous gastric surgery ; 3. Major systemic diseases ; 4. Pregnancy or lactation; 5. The use of antibiotics or yogurt within 2 months before the study.

Design outcomes

Primary

Measure	Time frame	Description
Change of gut microbiota after laparoscopic cholecystectomy	Three months and one year after completion of LC	Three months and one year after completion of laparoscopic cholecystectomy therapy, gut microbiota was assessed by 16S rDNA high-throughput sequencing.

Countries

China

Contacts

Primary ContactYingjie Ji, M.D.

jiyingjie39@outlook.com86+15800575527

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026