Cesarean Section Complications
Conditions
Keywords
Cesarean delivery
Brief summary
Compare 0.05 μg/kg/min Norepinephrine and 0.25 μg/kg/min phenylephrine effect on fetus and parturient during Cesarean Section
Detailed description
1. Compare 0.05 μg/kg/min Norepinephrine and 0.25 μg/kg/min phenylephrine and control group effect on parturient hemodynamic change (systolic blood pressure SBP, diastolic blood pressure DBP,mean arterial pressure MAP,heart rate HR) and on LIDICO-rapid monitoring ( stroke volume SV, systemic vascular resistance SVR, cardiac output CO) and peripheral vein (PV) blood gas during Cesarean Section. 2. Compare 0.05 μg/kg/min Norepinephrine and 0.25 μg/kg/min phenylephrine and control group effect on fetus by blood gas of the umbilical vein (UV), umbilical artery (UA),
Interventions
DRUGNorepinephrine
0.05ug/kg/min Norepinephrine during Cesarean Section Operation
DRUGPhenylephrine
0.25ug/kg/min phenylephrine during Cesarean Section Operation
3 ml/kg/min of LR was administrated according to standard weight.
Sponsors
China International Neuroscience Institution
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* a healthy singleton pregnancy scheduled for elective cesarean delivery (CD) under combined spinal-epidural anesthesia (CSEA), * American Society of Anesthesiologists (ASA) physical status I/II * 20 to 40 years old
Exclusion criteria
* history of mental disorder or epilepsy, * tricyclic or imipramine antidepressant use, * central nervous system (CNS) disease, * preexisting or pregnancy-induced hypertension, * lumbar injury, * severe hypovolemia, * allergy * history of hypersensitivity to vasopressor * body mass index (BMI) \>40 kg/m2, * infection at the puncture site
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Systemic vascular resistance (SVR) as the part of LIDICO-rapid monitoring parameter for parturient | Through study completion, an average of 24 hour | Systemic vascular resistance (SVR) |
| Heart rate (HR) change as the one of hemodynamic outcome in general monitoring | Through the study completion, an average of 24 hour | Heart rate (HR) |
| Stroke volume (SV) as the part of LIDICO-rapid monitoring parameter for parturient | Through study completion, an average of 24 hour | Stroke volume (SV) |
| Cardiac output (CO) as the part of LIDICO-rapid monitoring parameter for parturient | Through study completion, an average of 24 hour | Cardiac output (CO) |
| Systolic blood pressure (SBP) change as the one of hemodynamic outcome in general monitoring | through study completion, an average of 24 hour | Systolic blood pressure (SBP) |
| Diastolic blood pressure (DBP) change as the one of hemodynamic outcome in general monitoring | Through study completion | Diastolic blood pressure (DBP) |
| Mean arterial pressure (MAP) change as the one of hemodynamic outcome in general monitoring | An average of 24 hour | Mean arterial pressure (MAP) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The benefits to the fetus based on umbilical artery (UA) blood gas | Through study completion, an average of 24 hour | The umbilical artery (UA) blood gas |
| The benefits to parturient based on peripheral vein (PV) blood gas | Through study completion, an average of 24 hour | Peripheral vein (PV) blood gas |
| The benefits to the fetus based on umbilical vein (UV) blood gas | Through study completion, an average of 24 hour | The umbilical vein (UV) blood gas |
Countries
China
Outcome results
None listed