ART
Conditions
Brief summary
The current study aims to assess the effect of assisted hatching on the implantation rate of frozen blastocytes.
Detailed description
The Zona Pellucida protects the ovum from the penetration of multiple sperm, and from mechanical and physiological damage until the fertilized ovum reaches the uterus. Subsequently, spontaneous hatching occurs, and enables the embryo to attach to the endometrium. The technique of assisted hatching was originally investigated as a means to improve implantation in cases of zona hardening, and is commonly performed in 3-day embryos. In the current study, the investigators aim to investigate the effect of assisted hatching on 5-day frozen embryos.
Interventions
PROCEDUREAssisted hatching
Controlled hatching of the zona pellucida in the laboratory prior to embryo transfer
Sponsors
Wolfson Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* In-vitro fertilization patients at the investigators' institution, intended to undergo a transfer of a frozen five-day embryo (blastocyte) * 18 to 39 years old * First to third treatment cycle * Patient has previously had a maximum of four embryos transferred.
Exclusion criteria
* Over 40 years old * Congenital or acquired uterine malformations * Hydrosalpinx * Chronic autoimmune diseases * Embryo intended to be undergo preimplantation genetic diagnosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Implantation rate | Five to six weeks following embryo transfer | Number of gestational sacs demonstrated on ultrasound divided by the number of embryos transferred (expressed as percentage) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Chemical pregnancy | Five to six weeks following embryo transfer | Increase and subsequent decrease in beta HCG levels with no evidence of gestational sac on ultrasound |
| Early spontaneous abortion | Up to 15 weeks from embryo transfer | Spontaneous abortion of pregnancy during the first trimester of pregnancy |
Countries
Israel
Contacts
Primary ContactHadas Ganer Herman, MD
Outcome results
None listed