Heart Transplant Rejection
Conditions
Keywords
heart transplant
Brief summary
The researchers are trying to develop a way to measure the risk of transplant rejection with a blood test.
Detailed description
The study will utilize peripheral blood assays collected at time points that are considered standard of care at most institutions. Subjects will have peripheral blood collected at 1 month, 3 months, 6 months, and 12 months after heart transplantation, as well as any for cause time points. These samples will then be used for purposes of developing an RNA-seq based peripheral blood assay in adult heart transplant recipients.
Interventions
None listed
Sponsors
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients who meet all of the following criteria are eligible for enrollment as study participants: * Adult (≥18 years) solitary heart transplant recipient * Patient is willing and able to provide informed written consent
Exclusion criteria
Patients who meet any of these criteria are not eligible for enrollment as study participants: * Adult (\<18 years) heart transplant recipient * Patient refusal to enroll in the studyc3. Any simultaneous heart and extra organ transplant, including pancreas, liver, lung, kidney, etc. Subjects who have had previous transplants may be included.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| RNA-seq based peripheral blood assay in heart transplant recipients | 3 years | Cases will be reviewed and a subset of the peripheral blood specimens will be sent to Mayo Clinic Laboratories for development of the RNA-seq signature. The number of specimens analyzed will be determined based on the incidence of rejection and the incidence of biopsies for cause needed to develop the signature. |
Countries
United States
Outcome results
None listed