ART
Conditions
Brief summary
The current trial is intended to assess the efficacy of oral versus vaginal progesterone for luteal support in frozen IVF cycles.
Detailed description
Progesteron is used for luteal phase support in IVF cycles. Progesterone can be administered vaginally and orally. Duphaston is an oral progesterone drug, which has recentlly been proven effective in fresh cycle IVF. Yet, less is known regarding its efficacy in frozen cycle IVF. Thus, the objective of our trial is to compare the efficacy of vaginal and oral progesterone in frozen IVF cycles.
Interventions
Oral progesterone 10 mg TID
Vaginal Endometrin 100 mg twice daily
Sponsors
Wolfson Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* Ages 18-39 * Modified natural cycle (induction of ovulation with HCG) * Consent to participation
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Live birth rate | Up to 9 months | Birth of a live infant after 24 weeks gestation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | Outcome assesed 6-7 weeks following treatment | Viable pregnancy as demonstrated by ultrasound |
| Implantation rate | Outcome assessed 6-7 weeks following treatment | Number of gestational sacs divided by number of embryos transferred (percentage) |
Countries
Israel
Contacts
Primary ContactHadas Ganer Herman, MD
Outcome results
None listed