Cholangitis Infective, Elderly Person
Conditions
Keywords
critically ill, mortality, outcome, treatment intensity level
Brief summary
The aging of the population goes along with an increased demand for intensive care among very elderly patients (above 75-80 years old). At the same time, there is a decline in the supply of intensive care units (ICU). The 1-year mortality of patients above 80 years old in ICU ranged from 40 to 70%. Moreover, many survivors suffer from long-term sequelae as poor quality of life, cognitive impairment and functional disability. It is unclear under what conditions older patients may benefit from ICU admission. Cholangitis frequently occured in older patient. Moreover, severe acute cholangitis is a potentially life threatening disease characterized by a biliary obstruction and an infection of the bile possibly evolving towards systemic infection, shock and death. Because of its potential rapid reversibility of symptom thanks to early intravenous antibiotics and biliary decompression with drainage, old patients suffering from acute cholangitis are easily admitted to intensive care unit. To date, there is a lack of data about the outcome in this population admitted to the intensive care unit with acute cholangitis. The aim of the current study is to describe the outcomes in elderly patients (\> 75 years old) admitted to the ICU with acute cholangitis and to identify prognostics factors associated with long term mortality (6 months).
Interventions
None listed
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Inclusion criteria
* \> 65 years old * ICU admission for acute cholangitis * follow up in the same center after the ICU stay
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| mortality | 180 days | rate of survivors and non survivors |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| factors associated with 6 months mortality (underlying condition) | Day 1 | Functional status : presence or absence of denutrition defined by a BMI \< 19 kg/m2 and/or albuminemia \< 30 g/l and/or loss of weight \> 5% during the last month (or \> 10% during the last three months) |
| factors associated with 6 months mortality (severity score) | Day 1 | Simplified Acute Physiology Score 2 Minimum value : 0 / Maximun value 163 |
| factors associated with 6 months mortality (Presence of hemodynamic failure) | Up to 7 days | infusion of catecholamine (ie norepinephrine) during the ICU stay, yes or not |
| mortality | 90 days | rate of survivors and non survivors |
| factors associated with 6 months mortality (Presence of renal failure) | Up to 7 days | number od day(s) under renal replacement therapy |
| Clinical evolution | Day 3 | Change in Sequential Organ Failure score between Day 1 and Day 3. We measured the Sepsis-related Organ Failure Assessment (SOFA) score at day and day 3 and then made the difference between the two scores the SOFA score could range between 0 and 24 We calculated the score at day 1 and day 3 and made the difference An absence or a small difference between the 2 days is associated with a worse outcome |
| factors associated with 6 months mortality (Presence of respiratory failure) | Up to 7 days | number of day(s) under mechanical ventilation |
Countries
France
Outcome results
None listed