CT Angiography, Heart Failure, Heart Failure，Congestive, Heart Failure, Diastolic, Heart Failure, Systolic, Heart Rate Low, Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy
Conditions
Brief summary
The aim of this study is to compare the effects of Ivabradine and metoprolol to reduce heart rate prior to coronary CT angiography in patients with advanced heart failure.
Interventions
DRUGIvabradine
7.5 mg oral single dose if the heart rate would not reach to 60/minute then give another dose, 7.5 mg
DRUGMetoprolol
5 mg oral single dose if the heart rate would not reach to 60/minute then give another dose, 5 mg
Sponsors
Rajaie Cardiovascular Medical and Research Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Sinus rhythm * Heart rate \>60/min
Exclusion criteria
* Atrial fibrillation * Any contraindication for beta-blocker use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate | 30 minutes before and after coronary CT angiography | Changing heart rate during imaging study |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional calss | 30 minutes before and after coronary CT angiography and 6 months later | Heart Failure severity has been classified according to New York Heart Association (NYHA) to: * Class I: No limitation of physical activity. Ordinary physical activity does not cause symptoms of HF. * Class II: Slight limitation of physical activity. Comfortable at rest, but ordinary physical activity results in symptoms of HF. * Class III: Marked limitation of physical activity. Comfortable at rest, but less than ordinary activity causes symptoms of HF. * Class IV: Unable to perform any physical activity without symptoms of HF, or symptoms of HF at rest. |
| Blood pressure, systolic and diastolic | 30 minutes before and after coronary CT angiography and 6 months later | The amount of blood pressure measured by sphygmomanometer |
| Sleep quality | Before CT angiography and 6 months later | The rate of disturbed sleep measured as better than before, Worse than before, and No change There are no standard classification for severity of this symptom. In our study, we measure this symptom as : * Better than before (1) * Worse than before (2) * No change (0) |
| Dyspnea | 30 minutes before and after coronary CT angiography and 6 months later | Shortness of breath, or dyspnea, is the most famous symptom of left ventricular failure. It typically appears during strenuous activities, and progresses to ordinary activities, less than ordinary activities and ultimately resting state. The severity is categorized as above (FC 1 to 4) |
| Prolonged bradycardia | 30 minutes before and after coronary CT angiography | Persistence of Bradycardia more than 6 hours is called prolonged bradycardia. |
| Hypotension | 30 minutes before and after coronary CT angiography | Systolic less than 80 mm Hg |
| Appetite | Before CT angiography and 6 months later | The rate of changing in appetite level measured as better than before, Worse than before, and No change Loss of appetite is a common symptom of heart failure. There are no standard classification for severity of this symptom. In our study, we measure this symptom as : * Better than before (1) * Worse than before (2) * No change (0) |
Countries
Iran
Outcome results
None listed