Drug Effect
Conditions
Keywords
Sacubitril/Valsartan, Heart Failure, Ejection Fraction
Brief summary
Background: Sacubitril/valsartan, has been found to be more beneficial than enalapril for reducing the incidences of sudden cardiac death, death from worsening heart failure (HF), and hospitalization. However, there is no prospective echocardiographic data describing the effects of sacubitril/valsartan on the heart functions and left ventricular (LV) reverse remodeling. Therefore, the aim of our study was to evaluate the effects of sacubitril/valsartan on the LV functions using two dimensional (2D), three dimensional (3D) echocardiography and the 3D strain parameters. Methods: In 100 patients with HF with reduced ejection fraction (HRrEF) who have indications for the use of sacubitril/valsartan as recommended by recent guidelines were prospectively enrolled. The basal 2D and 3D echocardiographic parameters were compared to those obtained 3 months after starting the sacubitril/valsartan treatment.
Interventions
PROCEDUREEchocardiography
Basal two dimensional and three dimensional echocardiographic parameters were compared to those obtained 3 months after starting the sacubitril/valsartan treatment
Sponsors
The Young Investigator Group of Cardiovascular Research
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age is more than or equal 18 years old * Able to provide written informed consent * Indicated for the use of sacubitril/valsartan as recommended by the European Society of Cardiology (ESC) heart failure guidelines 2016 * Left ventricular ejection fraction of 40% or less
Exclusion criteria
* Cardiac resynchronization therapy (CRT) device implantation less than 3 months prior to the start of this study or CRT implantation intentions * Atrial fibrillation * Poor echocardiographic images * Sacubitril/valsartan treatment intolerance during the follow-up period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Two dimensional left ventricular ejection fraction | 3 months | Two dimensional ejection fraction is measured as baseline and after 3 months follow-up |
| Three dimensional left ventricular ejection fraction | 3 months | Three dimensional ejection fraction is measured as baseline and after 3 months follow-up |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Three dimensional left ventricular volumes | 3 months | Three dimensional left ventricular volumes are measured as baseline and after 3 months follow-up |
| Two dimensional left ventricular volumes | 3 months | Two dimensional left ventricular volumes are measured as baseline and after 3 months follow-up |
Outcome results
None listed