Acute Kidney Injury (Nontraumatic)
Conditions
Keywords
Acute kidney injury, Cardiac surgery, NGAL, GDF-15
Brief summary
Acute kidney injury (AKI) is the most common complication in patients after cardiac surgery. An usual estimation of risk for AKI is estimation of serum creatinine, which is unreliable indicator of AKI risk. Because of that, today different biomarkers are investigated to predict incidence for development AKI after cardiac surgery. This investigation will try to find potentially risk patients for developing AKI after cardiac surgery by using conventional markers (creatinine, glomerular filtration rate) in perioperative period comparing with two different biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and growth differentiation factor 15 (GDF-15) which are proven markers in patients with increased risk for AKI development.
Interventions
None listed
Sponsors
Nikola Bradic, MD
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* patients scheduled for cardiac surgery (CABG, valve replacement/repair, combined) * older than 18 years
Exclusion criteria
* previous known renal disease * patients on chronic dialysis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Consecutive values of neutrophil gelatinase-associated lipocalin (NGAL) | One year | By the changing of NGAL values in consecutive measuring, predict which patients are in increased risk for development of AKI |
| Consecutive values of growth differentiation factor 15 (GDF-15) | One year | By the changing of GDF-15 values in consecutive measuring, predict which patients are in increased risk for development of AKI |
| Consecutive values of glomerular filtration rate (GFR) | One Year | By the changing of GFR values in consecutive measuring, predict which patients are in increased risk for development of AKI |
Contacts
Primary ContactNikola Bradic, MD
Outcome results
None listed