Ketonemia
Conditions
Keywords
Ketones, Medium Chain Triglycerides, Glucose, Insulin, Free fatty acids
Brief summary
Compare plasma metabolites following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young and older participants.
Interventions
DIETARY_SUPPLEMENTNo MCT intake with breakfast, no lunch
Water given with a regular standardize breakfast and water given at noon without lunch.
DIETARY_SUPPLEMENTNo MCT intake with lunch, no breakfast
Water given in the beginning of the metabolic study day without breakfast and water given at noon with a regular standardize lunch.
DIETARY_SUPPLEMENT10g of Betaquik
BQ10 given with a regular standardize breakfast and BQ10 given at noon without lunch.
DIETARY_SUPPLEMENT10g of Betaquik with low-carbs breakfast
BQ10 given with a low-carbs standardize breakfast and BQ10 given at noon without lunch.
DIETARY_SUPPLEMENT20g of Betaquik
BQ20 given with a regular standardize breakfast and BQ20 given at noon without lunch.
DIETARY_SUPPLEMENT10g of Betaquik with lunch, no breakfast
BQ10 given in the beginning of the metabolic study day without breakfast and BQ10 given at noon with a regular standardize lunch.
Sponsors
Université de Sherbrooke
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
10 young and 10 older participants undergoing six separate but identical metabolic visits (interventions)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 10 health young (20-40 y old) and 10 health older (\> 60 y old) participants * Men and women
Exclusion criteria
* smoking * diabetes (fasting glucose \>7.0 mmol/l and glycated hemoglobin \>6.9%) * strenuous aerobic exercise more than three times a week * untreated hypertension, dyslipidemia, and abnormal renal, liver, heart or thyroid function * under medication known to affect triglycerides and carbohydrates metabolism (i.e. diuretics, beta-blockers, steroids, insulin sensitizing)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of plasma ketones (acetoacetate and B-hydroxybutyrate) | 8 hours | To compare acute ketonemia following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of plasma glucose | 8 hours | To compare acute glucose following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol. |
| Concentration of plasma insulin | 8 hours | To compare acute insulin following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol. |
| Concentration of plasma free fatty acids | 8 hours | To compare acute free fatty acids following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol. |
Countries
Canada
Outcome results
None listed