Labor Pain
Conditions
Brief summary
Misoprostol is a synthetic analogue of the naturally occurring prostaglandin E1. It was initially marketed for the treatment of peptic ulcers due to its mucosal protective and anti-secretory properties, but has commonly been used for the induction of abortion and labour .
Detailed description
Although initially having been established for oral use, misoprostol tablets are commonly used as vaginal suppositories for the previously purposes. Water or saline are frequently used in common practice to moisten the tablets prior to their administration, however, according to the pharmacokinetics of the drug, it should liquefy better in an acidic medium
Interventions
DRUGmisoprostol in a neutral media
giving misoprostol in a neutral media
DRUGmisoprostol in an acidic media
giving misoprostol in an acidic media
DRUGmisoprostol in an alkaline media
giving misoprostol in an alkaline media
Sponsors
Kasr El Aini Hospital
Aljazeera Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
3 paralle groups
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 42 Years
Healthy volunteers
Yes
Inclusion criteria
* Singleton pregnancies. Gestational age 38-41 weeks. Cephalic presentation
Exclusion criteria
* 1\. Multi-fetal pregnancy. 2. Pregnant women less than 38 weeks gestation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The number of women who will start lactive phase of labour after treatment | within 24 hours | the number of women in a group who will enter in active labour faster than other groups |
Countries
Egypt
Outcome results
None listed