Oral Health, Parkinson Disease
Conditions
Keywords
Oral Health, Parkinson Disease, Tooth cavities, Saliva, Mucosa
Brief summary
This is a prospective interventional clinical study whose main objective is to determine the impact of oral hygiene guidance on the oral health status of patients with Parkinson disease
Detailed description
Caries and periodontitis are infectious diseases that can eventually lead to the loss of the dental organ. The masticatory deficit engendered will have repercussions on the general state of the subject and on his quality of life (pains, difficulties of feeding which can cause nutritional deficiencies ...). The systematic review of the literature, despite low levels of evidence, shows that there is an influence of Parkinson's disease on oral health. Our goal is therefore to determine the impact of implementing appropriate oral hygiene measures on improving the quality of life of patients with Parkinson's disease. This is a 40-patient, interventional, preliminary study that will rely on indicators of oral health status (DMF, Periodontal Index, presence of pathogenic bacteria), as well as a questionnaire measuring impact of oral conditions on patient well-being (OHIP-14). These data will be collected before and after the implementation of the hygiene measures, within a period of 6 months.
Interventions
BEHAVIORALDelivery of oral hygiene advices
Patients will benefit from hygiene advice and maintenance of good oral health. No treatment will be administered as part of this study. Patients will continue their usual treatment according to the contraindications. Patients will benefit from salivary sampling and a collection of oral bacteria contained in the dental plaque using paper tips. These reviews will be conducted during the Inclusion Visit and the 6 month Follow-Up Visit.
Sponsors
Capionis
France Parkinson Association
University Hospital, Bordeaux
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Major patient * Patient with Parkinson disease * Able to give written informed consent * Affiliated to French health care system
Exclusion criteria
* Patient under tutorship and curatorship * Pregnant women * Patient wearing subtotal or total dental prosthesis * Antibiotic treatment or antiseptic mouthwashes in the month prior to sampling * Patient with less than 6 teeth distributed on maxilla and mandible
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Decayed Missing Filled (DMF) index score | 6 months after inclusion | Min value : 0 (good oral health), Max value : 32 |
| Presence of cariogenic bacteria in saliva and dental film | 6 months after inclusion | Streptococcus mutans and Lactobacillus |
| Presence of periodontopathogenic bacteria in saliva and dental film | 6 months after inclusion | Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Prevotella intermedia, Fusobacterium nucleatum, Peptostreptococcus micros, Eikenella corrodens, Campylobacter rectus |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of Oral Health Impact Profile-14 (OHIP-14) | Inclusion Visit (Day 0) and 6 month after | Min value : 14, Max value : 70 (satisfactory oral health) |
| Change of Geriatric/General Oral Health Assessment Index (GOHAI) | Inclusion Visit (Day 0) and 6 month after | Min value : 12, Max value : 60 (satisfactory oral health) |
| Decayed Missing Filled (DMF) index score | Inclusion visit (Day 0) | Min value : 0 (good oral health), Max value : 32 |
| Quantification of saliva flow | Inclusion Visit (Day 0) and 6 month after | Normal / Low |
| Change of Community Periodontal Index of Treatment Needs (CPITN) | Inclusion Visit (Day 0) and 6 month after | CPI Min value : 0 (healthy periodontium), Max value : 4 ; TN Min value : 0 (No periodontal treatment needed), Max value : 3 |
| Saliva pH | Inclusion Visit (Day 0) and 6 month after | Normal / Acid / Very acid |
| Presence of cariogenic bacteria in saliva and dental film | Inclusion visit (Day 0) | Streptococcus mutans and Lactobacillus |
| Presence of periodontopathogenic bacteria in saliva and dental film | Inclusion visit (Day 0) | Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Prevotella intermedia, Fusobacterium nucleatum, Peptostreptococcus micros, Eikenella corrodens, Campylobacter rectus |
Countries
France
Outcome results
None listed