Cesarean Section Complications
Conditions
Brief summary
The aim of this study is to compare the effects of intrathecal levobupivacaine plus midazolam and levobupivacaine plus fentanyl in patients undergoing caesarean section to get a prolonged postoperative analgesic effect and less side effects
Interventions
DRUGMidazolam
2 ml of 0.5% isobaric levobupivacaine (10 mg) plus 0.5 ml midazolam (2 mg)will be given intrathecally in L3 and L4 space with 25 gauge Quincke spinal needle via midline approach in sitting position. On free flow of cerebrospinal fluid, study drug will be injected intrathecally . Patients will immediately turn to supine position
DRUGFentanyl
2 ml of 0.5% isobaric levobupivacaine (10 mg) plus 0.5 ml fentanyl (25 μg)will be given intrathecally in L3 and L4 space with 25 gauge Quincke spinal needle via midline approach in sitting position. On free flow of cerebrospinal fluid, study drug will be injected intrathecally . Patients will immediately turn to supine position
Sponsors
Mohamed Abdelrady Mohamed
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients of American Society of Anaesthesiologists grades I and II ,
Exclusion criteria
* pre-existing neurological or spinal disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 1st post-operative analgesic request | 24-hour | pain will be evaluated using VAS score, every 30 min for 180 min then hourly for 12 h and thereafter every 3 hourly till 24 h of surgery in both groups. Rescue analgesia in the form of injection Ketorolac 30mg I.V when VAS \>3 in both groups. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| duration of sensory block Total analgesic consumption | 24-hour | total duration of sensory block (regression to S1 dermatome) will be noted |
Countries
Egypt
Outcome results
None listed