Different Modes of Ventilation During Cardiopulmonary Bypass

Comparative Study Between Different Modes of Ventilation During Cardiopulmonary Bypass and Its Effect on Postoperative Pulmonary Dysfunction

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03824301

Enrollment

Registered

2019-01-31

Start date

2017-01-22

Completion date

2018-11-20

Last updated

2019-01-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pulmonary Dysfunction

Keywords

cardiopulmonary bypass, pressure-controlled ventilation, volume-controlled ventilation, atelectasis, pleural effusion, lung compliance

Brief summary

66 patients divided into 3 groups with different modes of ventilation.

Detailed description

Sixty-six patients going through open-heart surgeries were included in the study, divided into 3 groups (P: pressure controlled ventilation, V: volume controlled ventilation, C: control) in accordance with the mode of ventilation. Patients studied for chest x-ray, lung ultrasound, arterial oxygen partial pressure to fractional inspired oxygen ratio (PaO2/FiO2), Alveolar-arterial oxygen gradient, static lung compliance and dynamic lung compliance, taken after induction of anesthesia, 1h post cardiopulmonary bypass, 1h after arrival to cardiac surgical unit.

Interventions

DEVICEVolume controlled ventilation

Changing modes of ventilation during cardiopulmonary bypass

DEVICEPressure controlled ventilation

Applying pressure controlled ventilation during cardiopulmonary bypass Period

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients undergoingvalve surgeries * Patients undergoing coronary artery bypass grafting surgeries

Exclusion criteria

* Emergency cases. * Off-pump surgeries. * Patients with chronic lung diseases with forced expiratory volume in first second (FEV1) or forced vital capacity (FVC) less than 40% of the predicted value. * Massive blood transfusion during surgery. * Complicated surgeries. * Redo surgeries. * Patients with decompensated heart failure prior to surgery. * Patients refusal

Design outcomes

Primary

Measure	Time frame	Description
chest x-ray	after induction of anesthesia, 1hour post cardiopulmonary bypass and 1hour after arrival to cardiac surgical unit.	Chest x ray to detect any lung pathology or changes from baseline like pleural effusion, pulmonary edema or pneumonia
lung ultrasonography	after induction of anesthesia, 1hour post cardiopulmonary bypass and 1hour after arrival to cardiac surgical unit.	Lung ultrasonography to detect any lung changes from baseline or development of consolidation, pulmonary edema or pleural effusion

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026