ECigs, Inflammation and Oxidative Stress

E-Cigarettes and Monocytes

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03823885

Enrollment

148

Registered

2019-01-31

Start date

2019-02-08

Completion date

2023-10-01

Last updated

2023-10-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E-cigarettes, Oxidative Stress, Inflammation

Brief summary

Randomized controlled trial of acute use of electronic cigarette effect on oxidative stress and inflammation.

Detailed description

Participants will have an acute e-cig exposure on 2 occasions 1) e-cigarette 2) sham e-cig (empty e-cig) control. Blood will be collected before and after E-cig use and analyzed for biomarkers of inflammation and oxidative stress.

Interventions

OTHERe-cigarette

use e-cig for 30 minutes

OTHERempty (-cigarette sham control)

use empty e-cig (sham control)

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Outcomes Assessor)

Masking description

Code

Intervention model description

Crossover with 2 week washout

Eligibility

Sex/Gender

ALL

Age

21 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy

Exclusion criteria

* Cardiac disease Respiratory disease Diabetes

Design outcomes

Primary

Measure	Time frame	Description
Cellular Reactive Oxygen Species, units = % fluorescence	within 4 hours of E-cig use	cellular oxidative stress, including cytoplasmic and mitochondrial oxidative stress, in viable cells

Secondary

Measure	Time frame	Description
CD 14+ Monocyte, units = % of total cells	within 4 hours of e-cig use	CD 14+ Monocyte, % of total cells will be measured with antibodies and stable dye

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 17, 2026