Trends in the Epidemiology and Treatment of Atopic Dermatitis in the United Kingdom (UK)

The Epidemiology of Atopic Dermatitis, Associated Comorbidities, and Treatment Patterns in the United Kingdom (UK)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03823794

Enrollment

148166

Registered

2019-01-30

Start date

2019-02-01

Completion date

2020-11-04

Last updated

2025-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atopic Dermatitis, Atopic Dermatitis Eczema, Eczema

Brief summary

Atopic dermatitis (AD), commonly called eczema, is one of the most frequently occurring skin conditions. It is estimated to affect around one fifth of children in developed countries and is also becoming increasingly common in less developed countries. Exact estimates of how common eczema is, vary considerably and there has not been an in-depth analysis of the number of people with eczema in the UK. It is also unclear which groups of people are most affected and which treatment options are being used. Most people with eczema are managed by their general practitioner (GP) with only a few people requiring specialist care. GP records therefore provide an excellent opportunity to explore how common eczema is and which treatments are being used currently.

Detailed description

Objective The study aims to describe the health care resource utilisation of patients with active AD in terms of prescription use, primary care appointments, and specialist referrals. Method This study will define AD cases using a previously validated algorithm for case identification use clinical codes form primary care in the UK (Read codes). The study will analyse a cohort of prevalent active AD cases over a one year period (2018). The annual use of topical and oral medications used for the treatment of AD, primary care appointments, and specialist referrals will be reported.

Interventions

OTHERNo intervention

Observational analysis of usual care only

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

0 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* All paediatric and adult patients registered with an Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) contributing GP practice during the study period (2008-2018) and with at least one year of follow-up.

Exclusion criteria

* The presence of psoriasis, photodermatitis, or ichthyosis

Design outcomes

Primary

Measure	Time frame	Description
Prescription Rates for Atopic Dermatitis Related Treatments: Emollients and Soap Substitutes	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for emollients and soap substitutes.
Prescription Rates for Atopic Dermatitis Related Treatments: Mild Topical Corticosteroids (TCS)	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for mild topical corticosteroids (atopic dermatitis related treatment)
Prescription Rates for Atopic Dermatitis Related Treatments: Moderate Topical Corticosteroids (TCS)	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for moderate topical corticosteroids (an atopic dermatitis related treatment)
Prescription Rates for Atopic Dermatitis Related Treatments: Potent Topical Corticosteroids (TCS)	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for potent topical corticosteroids (an atopic dermatitis related treatment)
Prescription Rates for Atopic Dermatitis Related Treatments: Very Potent Topical Corticosteroids (TCS)	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for very potent topical corticosteroid (an atopic dermatitis related treatment)
Prescription Rates for Atopic Dermatitis Related Treatments: Topical Calcineurin Inhibitors (TCI)	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for a topical Calcineurin Inhibitor (an atopic dermatitis related treatment)
Prescription Rates for Atopic Dermatitis Related Treatments: Topical Antimicrobials	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for topical antimicrobials.
Prescription Rates for Atopic Dermatitis Related Treatments: Antihistamin	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for antihistamin.
Prescription Rates for Atopic Dermatitis Related Treatments: Systemic Immuno-modulatory Therapy	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for Systemic immuno-modulatory therapy
Prescription Rates for Atopic Dermatitis Related Treatments: Oral Corticosteroids	Jan - Dec 2018 inclusive	Proportion of the arm/group receiving at least one prescription for oral corticosteroids
Specialist Referrals	Jan - Dec 2018 inclusive	Specialist dermatology referral rate in 2018
Primary Care Referrals	Jan - Dec 2018 inclusive	Annual rate of primary care consultations in 2018

Countries

United Kingdom

Participant flow

Participants by arm

Arm	Count
Active Atopic Dermatitis People fulfilling the diagnostic criteria for active atopic dermatitis during the calendar year 2018. Primary outcomes conducted within this single arm. No intervention: Observational analysis of usual care only	148,166
Total	148,166

Baseline characteristics

Characteristic	Active Atopic Dermatitis
Age, Customized Age Group 12-17	12476 Participants
Age, Customized Age Group 18-49	37995 Participants
Age, Customized Age Group <2	7230 Participants
Age, Customized Age Group 2-11	34074 Participants
Age, Customized Age Group >=50	56391 Participants
IMD quintile 1 (most deprived)	26454 Participants
IMD quintile 2	25520 Participants
IMD quintile 3	26445 Participants
IMD quintile 4	31426 Participants
IMD quintile 5 (least deprived)	36467 Participants
IMD quintile Missing	1854 Participants
Race/Ethnicity, Customized Ethnicity Asian	14980 Participants
Race/Ethnicity, Customized Ethnicity Black	5799 Participants
Race/Ethnicity, Customized Ethnicity Missing	35628 Participants
Race/Ethnicity, Customized Ethnicity Mixed	2808 Participants
Race/Ethnicity, Customized Ethnicity Other	1234 Participants
Race/Ethnicity, Customized Ethnicity White	87717 Participants
Rural-urban classification Missing	1695 Participants
Rural-urban classification Rural	29005 Participants
Rural-urban classification Urban	117466 Participants
Sex: Female, Male Female	81357 Participants
Sex: Female, Male Male	66809 Participants

Adverse events

Event type	EG000 affected / at risk
deaths Total, all-cause mortality	0 / 0
other Total, other adverse events	0 / 0
serious Total, serious adverse events	0 / 0