Hypoxia, Altitude
Conditions
Brief summary
This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups.
Detailed description
This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups. 15 different Groups are analysed: control Group, 5000ft Group, 8000 ft Group, 10000ft Group and 15000ft Group - all for 15, 30, and 60 minutes.
Interventions
PROCEDUREHypoxia
hypoxia
Sponsors
Universitätsklinikum Köln
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Masking description
volunteers
Intervention model description
15 different Groups are analysed: control Group, 5000ft Group, 8000 ft Group, 10000ft Group and 15000ft Group - all for 15, 30, and 60 minutes.
Eligibility
Sex/Gender
MALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Helathy
Exclusion criteria
* Ear problems
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Protein Expression before hypoxia | Measurement immediately 1 minute before of hypoxia/experiment | proteomic profiling of Serum by 2D-gels. All Proteins present in the sample will be identified by proteomics |
| Protein Expression after hypoxia | Measurement immediately and at termination (i.e., 1 minute after) of hypoxia/experiment | proteomic profiling of Serum by 2D-gels. All Proteins present in the sample will be identified by proteomics |
| Emotional assessment tears | Measurement starts immediately with hypoxia in the pressure chamber. duration 10 minutes | Emotional tears test |
| Emotional assessment | Measurement in the pressure chamber after tears test (i.e. 10 minutes after start). duration 10 minutes | Emotional stroop test; Williams, J. M. G., Mathews, A., & MacLeod, C. (1996). The emotional Stroop task and psychopathology. Psychological Bulletin, 120, 3-24. |
| Emotional assessment mood | Measurement in the pressure chamber after stroop test (i.e. 20 minutes after start). duration 10 minutes | Emotional mood test, POMS mood score. Shukitt-Hale, B., Banderet, L.E., & Lieberman, H.R. (1998). Elevation-dependent symptom, mood, and performance changes produced by exposure to hypobaric hypoxia, The International Journal of Aviation Psychology, 8, 319-334, |
Countries
Germany
Outcome results
None listed