Implementation of a Rapid Recovery Protocol in Total Knee Arthroplasty

Prospective Clinical Trial Regarding the Implementation of a Rapid Recovery Protocol in Total Knee Arthroplasty in Rio Hortega University Hospital

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03823573

Enrollment

175

Registered

2019-01-30

Start date

2019-01-10

Completion date

2020-12-31

Last updated

2023-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fast Track, Knee Osteoarthritis, Tranexamic Acid Adverse Reaction

Keywords

fast track, total knee arthroplasty, tranexamic acid, drain

Brief summary

Patients undergoing total knee arthroplasty will follow two different rehabilitation protocols. In one of them, they will start walking the day of surgery and discharged on a 48 hours basis. On the other one, start walking 3 days after surgery and discharged on a 96 hours basis. Outcomes will be satisfaction, pain, range of movement, incidence of DVT and overall complications.

Detailed description

Randomization will be performed concealed the day before surgery. Tranexamic acid will be used in both groups. Rapid recovery group will not be using a drain, whereas the standard protocol group will have one.

Interventions

BEHAVIORALWalk within 24 hours

Patients will start walking on different timings. Patients on the rapid recovery protocol won't be using drains.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

55 Years to 79 Years

Healthy volunteers

Inclusion criteria

* Knee osteoarthritis willing to undergo total knee arthroplasty * Age 55-79 * Consent

Exclusion criteria

* Hipersensibility to any of the components used * Epilepsy * Pulmonary embolism

Design outcomes

Primary

Measure	Time frame	Description
Pain: Morphine clorhydrate shots requested by the patient	24 hours	Number of shots requested and administered to the patient after surgery
Range of Motion	6 months	Knee range of motion measured in degrees of flexion (0-180º and extension (0-180º)
Ultrasonography incidence of deep vein thrombosis	4 weeks-8 weeks	Incidence of deep vein thrombosis measured by ultrasound
Overall score given by the patient to the knee replacement process	6 months	Satisfaction with the protocol. Subjective measure by the patient from 0 (bad) to 10 (best) with the surgery process.
Infection	1 year	Incidence of infection
Blood loss	48 hours	Haemoglobin drop
Oxford Knee Score pre op and post op	6 months	Difference in Oxford Knee Scores postoperatively and preoperatively

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 21, 2026