Pulmonary Ventilation
Conditions
Keywords
pediatric, Ventilation breathing tube, End-Tidal Carbon Dioxide, Heart rate, tidal volume, blood temperature
Brief summary
To discover whether different types of ventilation breathing tube influence ventilation effect of children/ neonate, the investigators analysis tidal volume, end tidal carbon dioxide, compliance among children and neonate under general anesthesia. The study compares eight ventilator breathing tube of different length, diameter, material of the ventilator breathing tube. Besides, the investigators also make an approach verify the change of body temperate under different gas flow(2L, and 5L).
Detailed description
In previous research, initial mechanical ventilator settings about children were as following: 1.tidal volume 6 to 10 ml/kg of ideal body weight; 2.delta pressures of respiratory pressure should be \<10 cmH2O in healthy patients; 3. respiratory pressures could be kept less than 28 to 30 cmH2O in patient with lung injury; 4. positive end-expiratory pressure was necessary, although the optimal level is unknown. However, few researches discussed about Influences of different types of ventilation breathing tube. The investigators want to clarify the character about length, diameter, and material of the ventilation breathing tube under the ventilation system in relation to tidal volume, end tidal carbon dioxide, compliance among children and neonate. During this study, the participants will be 100 children who were ASA class1, 2 and performed non-emergency, non-cardiac surgery, who will receive general anesthesia . The participants will divide into three groups according to different body weights (Group N: \<4.5kg; Group T: 4.5\ 20kg; Group C: \>20kg), and would receipt total eight type of ventilator breathing tube test. Primary outcome will be the difference of tidal volume, end tidal carbon dioxide and compliance. Besides, secondary outcome will be the change of body temperate under different gas flow (2L, and 5L).
Interventions
DEVICEVentilator breathing tube F2220
M: Folding D: 22mm; L: 2.0M
DEVICEVentilator breathing tube F2216
M: Folding; D: 22mm; L:1.6M
DEVICEVentilator breathing tube F1520
M: Folding; D: 15mm; L:2.0M
DEVICEVentilator breathing tube F1516
M: Folding; D: 15mm; L:1.6M
DEVICEVentilator breathing tube U1016
M: Unfolding; D: 10mm; L:1.6M
DEVICEVentilator breathing tube U1516
M: Unfolding; D: 15mm; L:1.6M
DEVICEVentilator breathing tube CA20
M: Co-axis; L:2.0M
DEVICEVentilator breathing tube CA16
M: Co-axis; L:1.6M
Sponsors
Mackay Memorial Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* with American Society of Anesthesiologists (ASA) physical status classification 1&2 * undergo elective surgery * intubation
Exclusion criteria
* Cardiac-pulmonary surgery * Had respiratory related disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tidal volume | From: 1 minute after endotracheal intubation, and vital signs include heart rate, blood pressure, EtCO2 did not change over 30%. To: eight types of tubes have already tested, up to 30 minutes after beginning | compared tidal volume besides different ventilation breathing tube |
| End tidal carbon dioxide | From: 1 minute after endotracheal intubation, and vital signs include heart rate, blood pressure, EtCO2 did not change over 30%. To: eight types of tubes have already tested, up to 30 minutes after beginning | compared End tidal carbon dioxide besides different ventilation breathing tube |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body temperate | From: 1 minute after endotracheal intubation, and vital signs include heart rate, blood pressure, EtCO2 did not change over 30%. To: eight types of tubes have already tested, up to 30 minutes after beginning | compared Body temperate about different gas flow(2L,5L) |
Countries
Taiwan
Outcome results
None listed