Emergencies
Conditions
Keywords
migraine, perfusion arterial, aura brain
Brief summary
The aim of the study is to determine the proportion of patients with change in brain perfusion during the acute phase of migraine attack with aura.
Detailed description
Migraine is a benign and frequent disorder. Migraine aura consists in reversible focal neurological symptoms developing gradually during attack. Its diagnosis relies mainly on patient's history, clinical examination and exclusion of other possible secondary causes to explain transient neurological signs. Thus it can be difficult particularly during first attack or during attack without headache to differentiate migraine aura from transient ischemic stroke. Considering the difference of care management and prognosis, an early distinction of migraine aura based on imaging techniques will have a particular interest. MRI with diffusion, SWI, Flair 2D, ARM 3D TOF, ASL sequences' are routinely performed for the management of acute neurological deficit. Arterial spin labeling (ASL), as a MR perfusion method, will be used to describe brain perfusion during migraine aura. The study hypothesis is that hyperperfusion occurs in brain territories corresponding to the neurological symptoms during migraine aura.
Interventions
OTHERthe difference of care management and prognosis, an early distinction of migraine aura based on imaging techniques will have a particular interest
the difference of care management and prognosis, an early distinction of migraine aura based on imaging techniques will have a particular interest
Sponsors
Nantes University Hospital
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age between greater than or equal to 18 * Able to undergo MRI during migraine aura
Exclusion criteria
* Pregnant females * Contraindications towards MRI scanning * History of epilepsy, psychiatric disease, or any other neurologic disease (brain tumors, stroke..). * Presence of abnormalities on the MRI that could explain the neurological deficit. * Adults under guardianship or trusteeship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Perfusion pattern of concerned brain areas | 1 hour | Presence or absence of hypo-hyperperfusion using arterial spin labeling. Visual assessments and comparison between hemispheres |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pattern of perfusion and aura duration | 12 month | Change in brain perfusion in relation to neurological deficits (migraine aura) duration. |
Countries
France
Outcome results
None listed