Coronary Artery Disease, Myocardial Infarction
Conditions
Keywords
exercise, interval training, continuous training, endothelial dysfunction
Brief summary
In this controlled trial, patients referred to post-myocardial infarction cardiac rehabilitation will be randomized to either interval or continuous training.
Detailed description
The trial would i) compare the acute effects of each exercise type on selected cardiovascular indicators; ii) compare the chronic effects of each exercise type on selected cardiovascular indicators; iii) provide information on the association between acute and chronic effects of each exercise type; iv) provide insight into possible mechanisms of effectiveness of each exercise type; v) identify the most safe and effective exercise type for patients with coronary artery disease.
Interventions
OTHERExercise training
Patients to be randomized to the 'interval training group' or 'continuous training group' will undergo exercise training sessions with different intensity levels.
Sponsors
University Medical Centre Ljubljana
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* myocardium infarction 120 days prior to cardiac rehabilitation
Exclusion criteria
* contraindications for exercise training, * uncontrolled dysrhythmias, * uncontrolled heart failure (New York Heart Association (NYHA) stage IV), * intellectual development disorder, * pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of flow-mediated dilatation of the brachial artery, measured in % | 3 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of the heart rate recovery | 3 months | — |
| Change in osteopontin and D-dimer levels, measured in microg/l | 3 months | — |
| Change in selectin and hsCRP, measured in mg/l | 3 months | — |
| Change in hsTnI, CK MB, endocan, sST2, galectin-3, NGAL, CD40 ligand and BDNF, measured in ng/l | 3 months | — |
| Change in copeptin levels, measured in pmol/l | 3 months | — |
| Change in MR-proADM and MR-proANP, measured in nmol/l | 3 months | — |
| Change in homoarginine, ADMA and SDMA levels, measured in micromol/l | 3 months | — |
| Change in fibrinogen and Lp(a) levels, measured in mg/dl | 3 months | — |
| Change in insuline level, measure in microIU/ml | 3 months | — |
| Change in total cholesterol, LDL, HDL, triglycerides and glucose levels, measured in mmol/l | 3 months | — |
| Change in overall haemostatic potential | 3 months | — |
| Change of the arterial stiffness coefficient | 3 months | — |
| Change of maximal oxygen uptake during exercise, measured in ml/kg/min | 3 months | — |
| Change of the heart rate variability | 3 months | — |
| Change in health-related quality of life using SF-36 questionnaire, measured in points | 3 months | It is a self-administered questionnaire comprising 36 items measuring eight dimensions and two subscales (physical and mental) |
| Change in IL-6, IL-8, IL-10, TNF-alpha and NT-proBNP levels, measured in ng/l | 3 months | — |
Other
| Measure | Time frame |
|---|---|
| Change in selectin and hsCRP during single exercise training session, measured in mg/l | 3 months |
| Change in hsTnI, CK MB, endocan, sST2, galectin-3, NGAL, CD40 ligand and BDNF levels during single exercise training session, measured in ng/l | 3 months |
| Change in copeptin levels during single exercise training session, measured in pmol/l | 3 months |
| Change in homoarginine, ADMA and SDMA levels during single exercise training session, measured in micromol/l | 3 months |
| Change in fibrinogen level during single exercise training session, measured in mg/dl | 3 months |
| Change in insuline levels during single exercise training session, measure in microIU/ml | 3 months |
| Change in osteopontin and D-dimer levels during single exercise training session, measured in microg/l | 3 months |
| Change in overall haemostatic potential during single exercise training session | 3 months |
| Change in IL-6, IL-8, IL-10, TNF-alpha and NT-proBNP levels during single exercise training session, measured in ng/l | 3 months |
| Change in the flow-mediated dilation during single exercise training session, measured in % | 3 months |
Countries
Slovenia
Outcome results
None listed