Evaluation of Novel Lung Function Parameters in Patients With Bronchial Asthma

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03820427

Enrollment

147

Registered

2019-01-29

Start date

2015-08-31

Completion date

2018-12-31

Last updated

2019-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchial Asthma, Pulmonary Healthy Controls

Brief summary

Current guideline-based criteria defining bronchial asthma do not always meet the challenges set by the complex pathophysiology of the disease. The investigators therefore aimed to evaluate novel or not widely used functional diagnostic approaches for the detection and therapeutic monitoring of patients with asthma.

Interventions

DIAGNOSTIC_TESTimpulse oscillometry

impulse oscillometry

DIAGNOSTIC_TESTmultiple breath washout test

multiple breath washout test

DIAGNOSTIC_TESTbody plethysmography

body plethysmography

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* known or suspected bronchial asthma * known or suspected obstructive ventilation disorder * pulmonary healthy controls

Exclusion criteria

* pregnancy * inability to participate

Design outcomes

Primary

Measure	Time frame	Description
Global ventilation heterogeneity	30 minutes	lung clearance index (LCI) derived from sulphur hexafluoride multiple breath washout
Local ventilation heterogeneity	30 minutes	Sacin, Scond (Phase III slopes) derived from sulphur hexafluoride multiple breath washout

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026