Kidney Graft
Conditions
Keywords
kidney graft, fibrosis, elastography
Brief summary
Kidney graft's fibrosis is correlated with prognostic of kidney's graft, wathever the initial etiology. Actually, that evaluation is based on histologic score of Banff FI/AT (0 to III). It is obtained thanks to punction-biopsy, which is invasive and can lead complications. This exam is systematic on M3 of the transplantation. Tissue's fibrosis is a proliferation of extracellular matrix, leading to an increase of fibrosed tissue rigidity. Elastography is an ultrasound technique allowing evaluation of tissues' rigidity. The purpose is the validation of elastograhpy, innovative and non -invasive technique, and more specifically Shear Wave Elastography (SWE). For this, strain ratio (SR) could improve intra-operator variability and estimate fibrosis' degree of kidney's graft.
Detailed description
Kidney graft's fibrosis is correlated with prognostic of kidney's graft, wathever the initial etiology. Actually, that evaluation is based on histologic score of Banff FI/AT (0 to III). It is obtained thanks to punction-biopsy, which is invasive and can lead complications. This exam is systematic on M3 of the transplantation. Tissue's fibrosis is a proliferation of extracellular matrix, leading to an increase of fibrosed tissue rigidity. Elastography is an ultrasound technique allowing evaluation of tissues' rigidity. The purpose is the validation of elastograhpy, innovative and non -invasive technique, and more specifically Shear Wave Elastography (SWE). For this, strain ratio (SR) could improve intra-operator variability and estimate fibrosis' degree of kidney's graft.
Interventions
None listed
Sponsors
University Hospital, Tours
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Kidney-transplanted patient, whatever kind of organ donation ( alive donor, deceased donor included extended criteria Maastricht 2 or 3) * More than 18 years-old
Exclusion criteria
* Dual kidney graft * Hydronephrosis / urinary obstacle * Pathologies with an intrinsic compression on the graft * Stenosis hemodynamically significant of graft artery (lengthening of Systolic Ascent Time \> 70 ms) * Contra-indication to systematical punction-biopsy on Month 3 : * Ischemia of post-transplanted graft * Alive donor HLA identical * Hemostasis disorder or unable to stop antiaggregant or anticoagulant * Hydronephrosis / urinary obstacle * Opposition to use the data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| measure of shear wave elastography | 3 months | Evaluation of shear wave elastography real time as biomarker of kidney graft's fibrosis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Strain Ratio measure | 3 months | \- Intra-operator variability of Strain Ratio measure |
Countries
France
Outcome results
None listed