Children, Adult, Univentricular Heart
Conditions
Keywords
Univentricular congenital heart, Sleep apnea, Polysomnography, Respiratory drive, VE/VCO2 slope
Brief summary
The aim is to evaluate the correlation between the respiratory control to hypercapnia at rest and the VE/VCO2 slope measured during cardiopulmonary exercise testing. The hypothesis is that patient with univentricular congenital heart disease have a increasing of respiratory drive like chronic heart failure. This increasing of respiratory drive could participate in the increasing of VE/VCO2 slope measured during cardiopulmonary exercise testing and in the genese of central apnea index during the sleep.
Detailed description
The patients with univentricular congenital heart disease will perform : * a cardiopulmonary exercise testing with measure VE/VCO2 slope, * a measure of the respiratory drive to hypercapnia with occlusion pressure during the rebreathing with at rest (P0,1/PetCO2). * A polysomnography with a scoring of central apnea index. Correlation will be evaluate between P 0,1/PetCO2 with VE/VCO2 slope and between P0,1/PetCO2 central apnea index.
Interventions
PROCEDUREpolysomnography
Sleep examination strictly non-invasive with skin sensors. This exploration would allow for the detection of respiratory sleep disorders and consider of appropriate management for patients.
Sponsors
University Hospital, Montpellier
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
all participants receive the same intervention throughout the protocol
Eligibility
Sex/Gender
ALL
Age
8 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Functionally univentricular congenital heart disease * Age ≥ 8 years * Consent of the adult patient or the parents or legal guardians of the minor patient. * Beneficiary of the social security scheme
Exclusion criteria
* Size \<120 cm (minimum size for the stress test) * Medical contraindication to exercise test or presence of : myocardial infarction less than 3 months old, unstable angina, uncontrolled severe arrhythmias, symptomatic aortic stenosis, uncontrolled heart failure, pulmonary embolism, evolutionary phlebitis, pericarditis, myocarditis, progressive endocarditis, aortic dissection * Unstable patient with severe intellectual disability or complex pathology making polysomnography impossible * Pregnant woman
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pearson correlation - The measure the respiratory drive to hypercapnia with P0.1 during the rebreathing technique at rest | day 90 after inclusion visit (visit 2) | between the measure the respiratory drive to hypercapnia with P0.1 during the rebreathing technique at rest \- between VE/VCO2 slope during a cardiopulmonary exercise |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pearson correlation | day 90 after inclusion visit (visit 2) | * between the measure of the respiratory drive to hypercapnia with P0.1, the rebreathing technique at rest and Central apnea index scored with a polysomnography during a night * between the measure of the respiratory drive to hypercapnia with P0.1, the rebreathing technique at rest and NYHA, New York Heart Association Functional Classification * between the measure of the respiratory drive to hypercapnia with P0.1, the rebreathing technique at rest and the quality of life evaluated by questionary * between the measure of the respiratory drive to hypercapnia with P0.1, the rebreathing technique at rest and data of cardiac echography |
Countries
France
Outcome results
None listed