Anesthesia
Conditions
Keywords
sedation, colonoscopy
Brief summary
To compare the anesthetic efficacy of the inhalation versus intravenous technique for maintenance of sedation in patients undergoing endoscopy. A longitudinal, randomized clinical study of 32 patients of both sexes ASA I-III, aged 18-80 years undergoing diagnostic colonoscopy, which was randomly divided into 2 groups. In both, intravenous induction with propofol (2-2.5 mg / kg) was performed, Group A remained sedated with propofol infusion (1-2 mg / kg / min); Group B by inhalation with sevoflurane at a concentration of 2 vol% through a nasal cannula with an oxygen flow.
Interventions
DRUGPropofol
after inicial bolus of propofol, remained sedated with propofol infusion (1-2 mg/kg/min)
DRUGSevoflurane
after inicial bolus of propofol, remained sedated by inhalation with sevoflurane at a concentration of 2 vol% through a nasal cannula with an oxygen flow.
Sponsors
Centro Medico Docente la Trinidad
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age between 18 and 80 years * physical status I, II and III according to the criteria of the American Society of Anesthesiology (ASA) * patients who are going to undergo diagnostic colonoscopies * patients who signed the informed consent
Exclusion criteria
* Allergy or hypersensitivity to some of the reference drugs in the study * patients with proven liver disease * suspicion or confirmation of pregnancy * antecedent or risk of malignant hyperthermia * fasting less than 8 hours * patients with psychic disorders or mental incapacity that make it difficult to understand their participation in the study * patients who have acute illnesses that compromise their health for which the study cannot be performed
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| oxygen saturation | During the colonoscopy - an estimated mean time of 20 minutes | pulse oximetry |
| The Recovery Time | 30 min | Every 5 minutes till a score of 10/10 achieved on Aldrete Score |
| Propofol dosage | During the colonoscopy - an estimated mean time of 20 minutes | propofol rescate bolus administered |
| arterial pressure | During the colonoscopy - an estimated mean time of 20 minutes | non invasive arterial pressure every 5 minutes |
| Heart rate | During the colonoscopy - an estimated mean time of 20 minutes | heart rate per minute |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Endoscopist Satisfaction | 60 min | Endoscopist Satisfaction scored from 1-10. Will be tested on a numerical scale from 0 (not satisfied at all) to 10 (fully satisfied) |
| Qualitatively assess patient comfort after sedation. | Up to 1 hour after completing the study. | poor, regular or good |
| adverse reactions in patients | 1 day (postoperative) | desaturation, laryngospasm |
Outcome results
None listed