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Effect of General Anesthesia on Early Postoperative Cognitive Function in Cesarean Section

Effect of General Anesthesia on Early Postoperative Cognitive Dysfunction in Elective Versus Emergency Cesarean Section

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03818009
Enrollment
58
Registered
2019-01-28
Start date
2019-01-14
Completion date
2020-09-20
Last updated
2020-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia Morbidity, Cesarean Section Complications

Keywords

Cognitive function postoperative

Brief summary

Cognitive dysfunction is the impairment of the mental process of perception, memory and information processing. The preoperative cognitive state is important, as mild cognitive impairment may be worsened following a cesarean section. Our study will aim to assess the incidence of early cognitive dysfunction after elective and emergent cesarean section under general anesthesia.

Detailed description

Mechanisms that lead to cognitive decline after anesthesia and surgery remain still unclear and mixed. Some studies suggested that an important role is played by the immune response to surgery. The inflammatory response could contribute to the development of postoperative cognitive decline (POCD0 through secretion of cortisol, cytokines, and other inflammatory mediators. Comparing the effects of general and spinal anesthesia on pregnant patients undergoing an elective cesarean section, found no cognitive change after both anesthesias. Our observational comparative study will be carried out at Beni Suef University Hospital. We will compare early cognitive functions undergoing general anesthesia in patients undergoing elective and emergency cesarean section.

Interventions

OTHERAssessment document

The anesthesiologist will evaluate through his sheet women's cognitive functions.

Sponsors

Beni-Suef University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
25 Years to 35 Years
Healthy volunteers
No

Inclusion criteria

* Women in reproductive age period between 25 and 35 years * Women booked for an elective or emergency cesarean section.

Exclusion criteria

* Mental disorder preoperative * Medical conditions ( as Hypertension or diabetes or cardiac diseases)

Design outcomes

Primary

MeasureTime frameDescription
postoperative cognitive decline (POCD)3 hours postoperativeNew impairment of memory directly post operative which will be assessed by psychometric questionnaire

Secondary

MeasureTime frameDescription
impaired performance on intellectual tasks3 days postoperativeNew impairment of using mind in daily tasks directly post operative which will be assessed through a questionnaire

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026