Effect of Dexmedetomidine and Propofol on Regional Cerebral Tissue Oxygen Saturation

The Effect of Continuous Propofol Versus Dexmedetomidine Infusion on Regional Cerebral Tissue Oxygen Saturation During Cardiopulmonary Bypass

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03817112

Enrollment

Registered

2019-01-25

Start date

2017-06-15

Completion date

2019-01-21

Last updated

2019-01-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Regional Cerebral Tissue Oxygen Saturation

Keywords

cerebral oxygen saturation, cardiopulmonary bypass, dexmedetomidine, propofol

Brief summary

50 patients divided into 2 groups .Group I Dexmedetomidine infusion. Group II with Propofol infusion

Detailed description

: 50 patients anticipated for open heart surgeries were encompassed in the study. Patients were divided into 2 groups, group P (receiving propofol) and group D (receiving dexmedetomidine) during CPB. Both groups were studied for variations in right and left rScO2 as well as postoperative cognitive dysfunction using the Mini Mental State Examination Score (MMSE) test.

Interventions

DRUGDexmedetomidine Hydrochloride 0.1 MG/ML

Dexmedetomidine Hydrochloride 0.1 MG/ML infusion at 0.2-0.7 mcg/kg/min

DRUGPropofol 10 MG/ML

Propofol 10 MG/ML infusion at 0.3 -4 mg/kg/h

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients undergoing valve surgeries * Patients undergoing on pump coronary artery bypass grafting surgeries

Exclusion criteria

* emergency cases, patients with cervical spine pathology (cervical stenosis, cervical disc herniation, carotid stenosis), patients with cerebral pathology (cerebral strokes, ischemic attacks), patients with Mini Mental State Examination Score (MMSE) of 23 or less, complicated cases with prolongation of the cardiopulmonary bypass period, patients needing moderate hypothermia

Design outcomes

Primary

Measure	Time frame	Description
cognitive function assessment	24 hours postoperative	Mini Mental State Examination Score (MMSE) test to assess orientation to time and place with ability to speak, think and draw. with highest ability 32 and lowest o

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026