Pain
Conditions
Keywords
multimodal, dexmedetomidine, ropivacaine, ketorolac, pain management, opioid sparing, analgesia
Brief summary
The investigators are performing this research study to investigate the efficacy of local infiltration of the surgical wound combining dexmedetomidine, ropivacaine, and ketorolac (treatment group) versus the current standard of care (historical control group), for post-operative pain management.
Detailed description
During this research study, patients recommended for a rectus sheath block during surgery will receive a novel combination of non-opioid drugs. Data from the treatment group will be compared to surgical outcomes of a historically matched control group to investigate the ability of this drug combination to reduce post-operative pain and post-operative opioid consumption.
Interventions
DRUGMultimodal analgesia
Subjects will be given a rectus sheath block containing dexmedetomidine, ropivacaine, and ketorolac
Sponsors
Massachusetts General Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Age greater than 18 years * American Society of Anesthesiologist Physical Status Classification 1-3 * Undergoing surgery requiring a rectus sheath block
Exclusion criteria
* American Society of Anesthesiologist Physical Status Classification of 4 or beyond * history of opiate of illicit substance abuse, chronic pain, or neurological dysfunction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in post-operative opioid consumption | 48 hours | Decreased post-operative opioid consumption associated with use of multimodal analgesia |
| Change in post-operative pain scores | 48 hours | Decreased post-operative pain scores associated with use of multimodal analgesia |
Outcome results
None listed