Changes in Elastic Properties of Descending Thoracic Aorta After Ascending Aorta Replacement

Impact of Ascending Aorta Replacement by Graft on Elastic Properties of Descending Thoracic Aorta Evaluated by Cardiac Magnetic Resonance Imaging

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03817008

Enrollment

Registered

2019-01-25

Start date

2014-09-01

Completion date

2019-01-17

Last updated

2019-01-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Surgery

Brief summary

The aim of our study was to evaluate the impact of aortic root replacement by a graft on the elastic properties of the descending thoracic aorta using cardiac Magnetic Resonance Imaging (MRI) and automatic post-processing. Nineteen patients were operated on an aortic root aneurysm and a cardiac MRI allowing aortic compliance measurement was performed before and after surgery. Images were acquired with a 1.5 T MRI with only one additional sequence to a conventional aortic MRI protocol.

Detailed description

Observational and retrospective trial on medical data only. The patients are operated of planned aortic root aneurysm without additional intervention. The pre and postoperative cardiac MRI are planned in standard of care.

Interventions

PROCEDUREAscending aorta replacement with graft

Patient with planned Ascending aorta replacement with graft

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Inclusion criteria

* \> 18 years * Elective patient * Ascending aorta replacement with graft

Exclusion criteria

* Prior cardiac surgery * Contraindication to performing cardiac MRI

Design outcomes

Primary

Measure	Time frame	Description
Aortic compliance of descending aorta (mm2/mmHg)	post-operative cardiac MRI performing between 12 and 24 months	Aortic elastic properties of the descending aorta before and after aortic root replacement using cardiac MRI. Aortic compliance is a local measurement of elastic properties which is obtained with cardiac MRI images by computer processing.

Secondary

Measure	Time frame	Description
Aortic compliance of ascending aorta (mm2/mmHg)	post-operative cardiac MRI performing between 12 and 24 months	Aortic elastic properties of the ascending aorta before and after aortic root replacement using cardiac MRI. Aortic compliance is a local measurement of elastic properties which is obtained with cardiac MRI images by computer processing.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 28, 2026