Natriuretic Peptides After Left Atrial Appendage Amputation

Influence of Left Atrial Appendage Amputation on Natriuretic Peptides - a Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03816410

Enrollment

Registered

2019-01-25

Start date

2015-05-01

Completion date

2018-12-01

Last updated

2019-01-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation

Brief summary

Surgical amputation of the left atrial appendage (LAA) is an established intervention during surgical atrial fibrillation (AF) therapy. However, its effects on the endocrine function of the left atrium are unclear. This study aims to quantify the serum levels of natriuretic peptides in patients who undergo concomitant surgical AF ablation with or without LAA amputation.

Interventions

PROCEDURELAA amputation

complete surgical amputation of the left atrial appendage

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Intervention model description

1:1 Randomization

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Indication for concomitant AF therapy during cardiac surgery with cardiopulmonary bypass

Exclusion criteria

* Lack of informed consent

Design outcomes

Primary

Measure	Time frame
Serum levels of proANP and BNP until 800days post surgery	800days

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026