Siderophore-profile in Allergic and Non-allergic Subjects

Linking Iron-deficiency With Allergy- the Role of Microbial Survival Components

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03815981

Enrollment

Registered

2019-01-25

Start date

2018-12-12

Completion date

2021-12-12

Last updated

2023-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Allergic Sensitisation, Allergy, Healthy

Keywords

iron, siderophores, allergy, allergic sensitisation, trace elements

Brief summary

This study aims to profile the siderophore-content in the human gut from allergic and non-allergic subjects and to assess their contribution in iron homeostasis.

Detailed description

Iron is an essential nutrient for the majority of commensal bacteria, which commonly secrete siderophores to liberate iron from their surroundings. In several studies, a misbalanced microbiota has been demonstrated in allergics suggesting that also their siderophore profile is severely attenuated. There are currently no data and very limited knowledge present on the composition of bacterial surviving factors in humans, or on their impact on the human immune system. As such, 1) the iron status, 2) the microbial biota composition and the 3) siderophore-profile in allergics and non-allergics will be assessed.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* allergic and non-allergic volunteers

Exclusion criteria

* Patients will not be considered for the study if they have co-morbidities such as diabetes mellitus, disorders of the liver including hemochromatosis or kidney, autoimmune or metabolic diseases and malignancy or if they use of medications (e.g. antibiotics, PPIs) that influence the iron, inflammatory or microbial status. Further

Design outcomes

Primary

Measure	Time frame	Description
Iron status	baseline	Hemoglobin, Ferritin, hepcidin, iron and soluble transferrin receptor concentrations, transferrin saturation in %

Secondary

Measure	Time frame	Description
Siderophore profile	baseline	Mass spectrometric analysis of siderophores

Countries

Austria

Outcome results