Invasive Pneumococcal Disease, Protection Against, Invasive Pneumococcal Disease, Recurrent Isolated, 1, Invasive Pneumococcal Disease, Recurrent Isolated, 2, Primary Immunodeficiency
Conditions
Keywords
streptococcus pneumoniae, invasive pneumococcal disease, primary immunodeficiency
Brief summary
This is a multicentre prospective audit to determine the incidence of immunodeficiency in children with IPD. Aims and/or research question of the project 1. To determine the incidence of primary immunodeficiency in children \>2 years who present with IPD 2. To determine the types of immunodeficiency associated with IPD in children
Interventions
OTHERReferral to Immunology
Screening for primary immunodeficiency including splenic dysfunction
Sponsors
Royal Children's Hospital
Murdoch Childrens Research Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Months to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Children aged 0 to 18 years admitted to one of the six centres with IPD.
Exclusion criteria
* Children who do not fulfil the age criteria for immunological evaluation at that particular site e.g. aged \<2 years at Royal Children's Hospital. * Children with a known underlying condition predisposing to IPD i.e. nephrotic syndrome.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence of primary immunodeficiency in children who present with invasive pneumococcal disease | 3 years | This will be picked up upon prospective immunological testing, after identification of patients with invasive pneumococcal disease. A series of tests will be performed depending on the clinical opinion of the immunology team. Such tests may include lymphocyte subsets, complement function, serum immunoglobulin levels, memory B cells, vaccine antibody responses, etc. |
| types of immunodeficiency associated with children who present with invasive pneumococcal disease | 3 years | This will be determined based on the testing performed by the immunologists. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| whether increased referrals of children who present with invasive pneumococcal disease for investigation of primary immunodeficiency facilitates early detection | 3 years | This information will come from reviewing the case series of patients who are identified from this study. The incidence of those with primary immunodeficiency will be analysed against known background rates of diagnoses. |
Countries
Australia, New Zealand
Outcome results
None listed