Metabolic Syndrome
Conditions
Keywords
insulin resistance, blood pressure,
Brief summary
This study evaluates the effect of a combination of glycirrhizic acid, Cinnamomun Zeylanicum and corosolic acid for the treatment of metabolic syndrome. Participants receive the supplement or a placebo.
Detailed description
The supplement is composed by of a combination of glycirrhizic acid, Cinnamomun Zeylanicum and corosolic acid. They act in different way reducing insulin resistance, which is the main cause of metabolic syndrome. It was a randomized, controlled study involving 60 women with the metabolic syndrome following the criteria proposed by ATP III in 2015. Main outcomes were the improvement of the parameters that characterizes the metabolic syndrome, such as glucose and insulin levels, triglycerides, HDL-cholesterol and blood pressure.
Interventions
DIETARY_SUPPLEMENTSineos
glycyrrhizic acid 38 mg + Cinnamomum Zeylanicum 150 mg + corosolic acid 480 mcg 2 pills per day
Sponsors
University of Messina
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
45 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Postmenopausal women affected by Metabolic Syndrome, diagnosed by ATP 2015 criteria. \-
Exclusion criteria
treatment with steroids or with hypoglycemic or anti-cholesterol drugs \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in glycemia | 3 months | Reduction of glycemia (mg/dl) |
| Changes in HDL-cholesterol | 3 months | Increase of HDL-C (mg/dl) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes in HOMA-IR | 3 months | measured as the ratio between glycaemia (mg/dl) and insulin (UI) |
| changes in total-cholesterol | 3 months | reduction of cholesterol (mg/dl) |
| changes in triglycerides | 3 months | reduction in triglycerides (mg/dl) |
Outcome results
None listed